Ara mostrant els elements 221-240 de 634

    Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins 

    Softic, Samir; Meyer, Jesse G.; Wang, Guo-Xiao; Gupta, Manoj K; Batista, Thiago M; Lauritzen, Hans P M M; Fujisaka, Shiho; Serra i Cucurull, Dolors; Herrero Rodríguez, Laura; Willoughby, Jennifer; Fitzgerald, Kevin; Ilkayeva, Olga; Newgard, Christopher B; Gibson, Bradford W; Schilling, Birgit; Cohen, David E; Kahn, C. Ronald (Data de publicació: 2020-07-06)

    Dietary sugars, fructose and glucose, promote hepatic de novo lipogenesis and modify the effects of a high-fat diet (HFD) on the development of insulin resistance. Here, we show that fructose and glucose supplementation ...

    Overcoming MDR by Associating Doxorubicin and pH-Sensitive PLGA Nanoparticles Containing a Novel Organoselenium Compound-An In Vitro Study 

    Macedo, Letícia B.; Nogueira, Daniele R.; Mathes, Daniela; Melo de Vargas, Josiele; Mello da Rosa, Raquel; Dorneles Rodrigues, Oscar Endrigo; Vinardell Martínez-Hidalgo, Ma. Pilar; Mitjans Arnal, Montserrat; Bueno Rolim, Clarice Madalena (Data de publicació: 2022-05-26)

    : In this study, we developed PLGA nanoparticles (NPs) as an effective carrier for 50 -Se- (phenyl)-3-(amino)-thymidine (ACAT-Se), an organoselenium compound, nucleoside analogue that showed promising antitumor activity ...

    Dual responsive gelatin-based nanoparticles for enhanced 5-fluorouracil efficiency 

    Morán Badenas, María del Carmen; Carazo, Javier; Busquets i Viñas, Ma. Antonia (Data de publicació: 2020-07-14)

    The very slow progress in the therapeutic efficacy of the treatment of severe diseases has suggested the use of a growing need for a multidisciplinary approach to the delivery of therapeutics to targets tissues. There has ...

    Valoració de l'avaluació continuada a l'assignatura Fisiologia i Fisiopatologia III del Grau de Farmàcia 

    Pelegrí i Gabaldà, Carme; Martín Venegas, Raquel; Moreno Aznárez, Juan José; Rabanal i Tornero, Manel; Pérez Bosque, Anna; Vilaplana i Hortensi, Jordi; Ferrer i Roig, Ruth (Data de publicació: 2014-03-04)

    Podeu consultar la Setena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/43352

    DNA gel particles: An overview 

    Morán Badenas, María del Carmen; Vinardell Martínez-Hidalgo, Ma. Pilar; Infante Martínez-Pardo, Ma. Rosa; Miguel, M. Graça; Lindman, Björn, 1942- (Data de publicació: 2019-02-04)

    A general understanding of interactions between DNA and oppositely charged compounds forms the basis for developing novel DNA-based materials, including gel particles. The association strength, which is altered by varying ...

    Methodological shortcomings in the reports of the imiquimod psoriatic model 

    Vinardell Martínez-Hidalgo, Ma. Pilar (Data de publicació: 2021-12-21)

    Psoriasis is a chronic inflammatory skin disease affecting about 2-3% of the worldwide population. More of the knowledge of psoriasis is due to the in vitro and in vivo models tried to reproduce the disease and to know the ...

    Microglial Adenosine Receptors: From Preconditioning to Modulating the M1/M2 Balance in Activated Cells 

    Franco Fernández, Rafael; Lillo, Alejandro; Rivas‐Santisteban, Rafael; Reyes Resina, Irene; Navarro Brugal, Gemma (Data de publicació: 2022-03-30)

    Neuronal survival depends on the glia, that is, on the astroglial and microglial support. Neurons die and microglia are activated not only in neurodegenerative diseases but also in physiological aging. Activated microglia, ...

    Bioavailability and metabolism of maslinic acid, a natural pentacyclic triterpene 

    Juan i Olivé, M. Emília; Planas i Rosselló, Joana M. (Data de publicació: 2016-11-24)

    Podeu consultar el llibre complet a: http://hdl.handle.net/2445/103042

    HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism 

    Du, Weinan; Zhang, Luchang; Brett-Morris, Adina; Aguila, Brittany; Kerner, Janos; Hoppel, Charles L.; Puchowicz, Michelle; Serra i Cucurull, Dolors; Herrero Rodríguez, Laura; Rini, Brian I.; Campbell, Steven; Welford, Scott M. (Data de publicació: 2018-01-31)

    Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxiainducible factors (HIFs) are the most ...

    Efecte de diferents fonts de seleni sobre la funció intestinal de barrera 

    Moral Anter, David; Campo Sabariz, Joan; Ferrer i Roig, Ruth; Martín Venegas, Raquel (Data de publicació: 2021-03-18)

    In the production of meat chickens it is necessary to complement their diet with selenium in order to ensure optimum growth, reproduction, and health. In the intestine, the main function of selenium is the synthesis of ...

    Oral Serum-Derived Bovine Immunoglobulin/Protein Isolate Has Immunomodulatory Effects on the Colon of Mice that Spontaneously Develop Colitis 

    Pérez Bosque, Anna; Miró Martí, Ma. Lluïsa; Maijó Ferré, Mònica; Polo Pozo, Francisco Javier; Campbell, Joy M.; Russell, Louis; Crenshaw, Joe D.; Weaver, Eric; Moretó, Miquel, 1950- (Data de publicació: 2016-12-01)

    Dietary immunoglobulin concentrates prepared from animal plasma can modulate the immune response of gut-associated lymphoid tissue (GALT). Previous studies have revealed that supplementation with serum-derived bovine ...

    Artritis reumatoide: etiologia i patogènesi 

    Franch i Masferrer, Àngels; Astell, Margarida; Pelegrí i Gabaldà, Carme (Data de publicació: 2019-01-16)

    L'artritis reumatoide és una malaltia crònica caracteritzada per ]a inflamació de ]a membrana sinovial i que pot donar lloc a deformacions i incapacitació final de les articulacions afectades. La causa d'aquesta malaltia ...

    Effects of dietary carbohydrate on hepatic de novo lipogenesis in European seabass (Dicentrarchus labrax L.) 

    Viegas, Iván; Jarak, Ivana; Rito, Joao; Carvalho, Rui A.; Metón Teijeiro, Isidoro; Pardal, Miguel A.; Baanante, Isabel V.; Jones, John G. (Data de publicació: 2020-06-16)

    Farmed seabass have higher adiposity than their wild counterparts and this is often attributed to carbohydrate (CHO) feeding. Whether this reflects a reduction in fat oxidation, increased de novo lipogenesis (DNL), or both, ...

    Influenza syndromic surveillance based on sentinel pharmacies in Catalonia (Spain) in 2017-2020 

    Plans-Rubió, Pedro; Jambrina Albiach, Anna Maria; Carmona, Gloria; Rabanal i Tornero, Manel; Jané, Mireia; Rius, Pilar (Data de publicació: 2021-07-29)

    Objective: To analyse influenza surveillance data obtained from sentinel pharmacies of Catalonia, Spain, in 2017−18, 2018−19 and 2019-20 influenza seasons. Methods: Influenza surveillance information was collected from a ...

    Dietary Options for Rodents in the Study of Obesity 

    Bastías-Pérez, Marianela; Serra i Cucurull, Dolors; Herrero Rodríguez, Laura (Data de publicació: 2020-10-29)

    Abstract: Obesity and its associated metabolic diseases are currently a priority research area. The increase in global prevalence at different ages is having an enormous economic and health impact. Genetic and environmental ...

    2-Hydroxy-(4-methylseleno)butanoic acid is used by intestinal Caco-2 Cells as a source of selenium and protects against oxidative stress 

    Campo Sabariz, Joan; Moral Anter, David; Brufau Bonet, M. Teresa (Maria Teresa; Briens, M.; Pinloche, Eric; Ferrer i Roig, Ruth; Martín Venegas, Raquel (Data de publicació: 2025-01-23)

    <p>Background: Selenium (Se) participates in different functions in humans and other animals through its incorporation</p><p>into selenoproteins as selenocysteine. Inadequate dietary Se is considered a risk factor for ...

    Alternativas a los animales de laboratorio en docencia 

    Vinardell Martínez-Hidalgo, Ma. Pilar (Data de publicació: 2015-04-10)

    En este artículo se hace una revisión sobre la utilización de animales y de métodos alternativos en docencia y se constata que todavía se siguen utilizando animales, a pesar de los avances tecnológicos que permiten cada ...

    Immunomodulatory and Prebiotic Effects of 2'-Fucosyllactose in Suckling Rats 

    Azagra Boronat, Ignasi; Massot Cladera, Malen; Mayneris-Perxachs, Jordi; Knipping, K.; van't Land, B.; Tims, S.; Stahl, B.; Garssen, J.; Franch i Masferrer, Àngels; Castell, Margarida; Rodríguez Lagunas, María José; Pérez-Cano, Francisco J. (Data de publicació: 2020-05-14)

    Human milk oligosaccharides are unconjugated complex glycans present in high concentration in human milk that serve as pre-biotics and immunomodulators. They are not primarily absorbed or metabolized by the infant and reach ...

    Absorció d'hexoses a través de l'epiteli intestinal. 

    Planas i Rosselló, Joana M.; Amat, Concepció; Ferrer i Roig, Ruth; Moretó, Miquel, 1950- (Data de publicació: 2019-01-16)

    En aquesta revisió es fa una recopilació dels coneixements actuals sobre els mecanismes implicats en 1'absorció intestinal de monosacàrids. A més dels mecanismes inespecífics,caracteritzats pel moviment passiu a favor de ...

    Downregulation of Tomato STEROL GLYCOSYLTRANSFERASE 1 Perturbs Plant Development and Facilitates Viroid Infection 

    Cisneros, Adriana E.; Lisón, Purificación; Campos, Laura; López-Tubau, Joan Manel; Altabella Artigas, Teresa; Ferrer i Prats, Albert; Daròs, José-Antonio; Carbonell, Alberto (Data de publicació: 2023-02-15)

    Potato spindle tuber viroid (PSTVd) is a plant pathogen naturally infecting economically important crops such as tomato (Solanum lycopersicum). Here, we aimed to engineer tomato plants highly resistant to PSTVd and developed ...