Bioquímica i Biomedicina Molecular: Enviaments recents
Ara mostrant els elements 81-100 de 918
Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds
Arabidopsis thaliana contains two genes encoding farnesyl diphosphate (FPP) synthase (FPS), the prenyl diphoshate synthase that catalyzes the synthesis of FPP from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate ...
El futur del país no és cosa de científics
Els països que volen ser líders no dubten a fer polítiques clares i explícites. Es veu tant en el pressupost com en l'acció política. No és el cas de Catalunya i jo estic decebut. No ara, la meva decepció és d'anys. El ...
Modulation of rat liver urea cycle and related ammonium metabolism by sex and cafeteria diet
High-energy (hyperlipidic) cafeteria diets induce insulin resistance limiting glucose oxidation, and lower amino acid catabolism. Despite high amino-N intake, amino acids are preserved, lowering urea excretion. We analysed ...
Cannabinoid receptors CB1 and CB2 form functional heteromers in the brain
Exploring the role of cannabinoid CB2 receptors in the brain, we present evidence of CB2 receptor molecular and functional interaction with cannabinoid CB1 receptors. Using biophysical and biochemical approaches, we ...
Nuclear magnetic resonance in conjunction with functional genomics suggests mitochondrial dysfunction in a murine model of cancer cachexia
Cancer patients commonly suffer from cachexia, a syndrome in which tumors induce metabolic changes in the host that lead to massive loss in skeletal muscle mass. Using a preclinical mouse model of cancer cachexia, we tested ...
Unveiling a key role of oxaloacetate-glutamate interaction in regulation of respiration and ROS generation in nonsynaptic brain mitochondria using a kinetic model.
Glutamate plays diverse roles in neuronal cells, affecting cell energetics and reactive oxygen species (ROS) generation. These roles are especially vital for neuronal cells, which deal with high amounts of glutamate as a ...
La Universitat ens ajudarà a sortir de la crisi?
La Universitat no ha de ser un centre de formació professional, i en general no prepara per professions específiques, però sí que pot afavorir l'adquisició d'eines necessàries en el món professional, entre les quals l'esperit ...
A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease
Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic liver disease (ACLD) and portal hypertension (PH). Considering the current lack of effective treatments, we evaluated an ...
Maslinic acid, a natural Triterpene, induces a death receptor-mediated apoptotic mechanism in Caco-2 p53-deficient colon adenocarcinoma cells
Maslinic acid (MA) is a natural triterpene present in high concentrations in the waxy skin of olives. We have previously reported that MA induces apoptotic cell death via the mito- chondrial apoptotic pathway in HT29 colon ...
Fighting rheumatoid arthritis: Kv1.3 as a therapeutic target
Abstract Rheumatoid arthritis (RA) is a serious autoimmune disease that has severe impacts on both the wellbeing of patients and the economy of the health system. Similar to many autoimmune diseases, RA concurs with a long ...
Membrane Heteroreceptor Complexes as Second-Order Protein Modulators: A Novel Integrative Mechanism through Allosteric Receptor–Receptor Interactions
Bioluminescence and fluorescence resonance energy transfer (BRET and FRET) together with the proximity ligation method revealed the existence of G-protein-coupled receptors, Ionotropic and Receptor tyrosine kinase ...
Metformin lowers Glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation
The chronic effects of metformin on liver gluconeogenesis involve repression of the G6pc gene, which is regulated by the carbohydrate-response element-binding protein through raised cellular intermediates of glucose ...
Targeted Metabolomics Shows That the Level of Glutamine, Kynurenine, Acyl-Carnitines and Lysophosphatidylcholines Is Significantly Increased in the Aqueous Humor of Glaucoma Patients.
The composition of the aqueous humor of patients with glaucoma is relevant to understand the underlying causes of the pathology. Information on the concentration of metabolites and small molecules in the aqueous humor of ...
Traslladar el coneixement
A Catalunya, a diferència d'altres països, no tenim eines públiques que afavoreixin que el fruit de la recerca serveixi per desenvolupar noves empreses de base científica. No tenim els mecanismes financers ni la cultura ...
Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41
The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during HIV-1 entry. Here we ...
Effect of sex on glucose handling by adipocytes isolated from rat subcutaneous, mesenteric and perigonadal adipose tissue (Raw data)
Dades primàries associades a un article publicat a la revista PeerJ https://doi.org/10.7717/peerj.5440
Les comunitats d'innovació
La missió d'InnoLife és promoure l'esperit empresarial i el desenvolupament d'innovacions en la vida sana i l'envelliment actiu, dotar Europa de noves oportunitats i recursos. Entre altres ambiciosos objectius, el consorci ...
Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction
Mitochondrial dynamics is a term that encompasses the movement of mitochondria along the cytoskeleton, regulation of their architecture, and connectivity mediated by tethering and fusion/fission. The importance of these ...
Neuroprotective compounds alter the expression of genes coding for proteins related to mitochondrial function in activated microglia
A hallmark of neuroinflammatory disorders is mitochondrial dysfunction. Nevertheless, the transcriptional changes underlying this alteration are not well-defined. Microglia activation, a decrease in mitochondrion biogenesis ...
Rapid perioperative changes in the quantitative properties of plasma lipases and lipoproteins in morbidly obese surgical patients'
Background: The impact of bariatric surgery on abnormalities in blood lipids and lipoprotein metabolism during the perioperative period has been poorly studied. Objective: We studied the impact of bariatric surgery on the ...
