Biomedicina: Enviaments recents
Ara mostrant els elements 281-300 de 779
STAT3 and REDD1: an unconventional story of gene repression
The non-canonical functions of the transcription factor STAT3 have been poorly studied in comparison to its canonical mechanisms of gene expression activation. Here, Köhler et al. put the spotlight on a novel unconventional ...
Subversion of Natural Killer Cell Responses by a Cytomegalovirus-encoded Soluble CD48 decoy receptor
Throughout evolution, cytomegaloviruses (CMVs) have been capturing genes from their hosts, employing the derived proteins to evade host immune defenses. We have recently reported the presence of a number of CD48 homologs ...
α4-α5 helices on surface of KRAS can accommodate small compounds that increase KRAS signaling while inducing CRC cell death
Abstract: KRAS is the most frequently mutated oncogene associated with the genesis and progress of pancreatic, lung and colorectal (CRC) tumors. KRAS has always been considered as a therapeutic target in cancer but until ...
Viral enhancer mimicry of host innate-immune promoters
The inflammatory milieu is the natural habitat for a pathogenic infection, characterised by activity of pro-inflammatory signalling pathways and inflammatory cytokines. Viral entry rapidly activates a range of innate-immune ...
Mast Cells: When the Best Defense Is an Attack?
The main goal of this Special Issue was to highlight the recent advances made on the role of mast cells (MCs) in host defense and pathology. MCs are recognized as crucial initiators and regulators of both innate and adaptive ...
<em>Microglial CD300f immune receptor contributes to the maintenance of neuron viability in vitro and after a penetrating brain injury</em>
Emerging evidences suggest that immune receptors participate in diverse microglial and macrophage functions by regulating their immunometabolism, inflammatory phenotype and phagocytosis. CD300f, a TREM2-like lipid sensing ...
Low-Cost Open-Source Device to Measure Maximal Inspiratory and Expiratory Pressures
The measurement of maximal inspiratory (MIP) and maximal expiratory (MEP) pressures is a widely used technique to non-invasively evaluate respiratory muscle strength in clinical practice. The commercial devices that perform ...
Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility
Several factors present in the extracellular environment regulate epithelial cell adhesion and dynamics. Among them, growth factors such as EGF, upon binding to their receptors at the cell surface, get internalized and ...
Effect of Specific Mutations in Cd300 Complexes Formation; Potential Implication of Cd300f in Multiple Sclerosis.
Herein, we have used bioinformatics tools to predict five clusters defining ligand-binding sites on the extracellular domain of human CD300b receptor, presumably involved in the formation of both homodimers and heterodimers ...
Regulation of protein transport from the Golgi complex to the endoplasmic reticulum by CDC42 and N-WASP.
Actin is involved in the organization of the Golgi complex and Golgi-to-ER protein transport in mammalian cells. Little, however, is known about the regulation of the Golgi-associated actin cytoskeleton. We provide evidence ...
Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels
Huntington's disease (HD) is a polyglutamine disorder caused by a CAG expansion in the Huntingtin (HTT) gene exon 1. This expansion encodes a mutant protein whose abnormal function is traditionally associated with HD ...
The transcriptional co-activator PCAF regulates cdk2 activity.
Cyclin dependent kinases (cdks) regulate cell cycle progression and transcription. We report here that the transcriptional co-activator PCAF directly interacts with cdk2. This interaction is mainly produced during S and ...
Desarrollo, seguimiento y evaluación de la formación especializada en el modelo troncal.
La implantación de la troncalidad en la formación sanitaria especializada en España es el cambio más profundo y complejo que se introduce en la regulación del sistema de formación especializada desde el año 1978. Este hecho ...
Soluble mutant huntingtin drives early human pathogenesis in Huntington's disease
Huntington's disease (HD) is an incurable inherited brain disorder characterised by massive degeneration of striatal neurons, which correlates with abnormal accumulation of misfolded mutant huntingtin (mHTT) protein. ...
Activation of Siglec-7 Results in Inhibition of in Vitro and in Vivo Growth of Human Mast Cell Leukemia Cells
Advanced systemic mastocytosis is a rare and still untreatable disease. Blocking antibodies against inhibitory receptors, also known as 'immune checkpoints', have revolutionized anti-cancer treatment. Inhibitory receptors ...
The plasma membrane as a mechanochemical transducer
Cells are constantly submitted to external mechanical stresses, which they must withstand and respond to. By forming a physical boundary between cells and their environment that is also a biochemical platform, the plasma ...
Annexin A6 is critical to maintain glucose homeostasis and survival during liver regeneration in mice
Background and aims: Liver regeneration requires the organized and sequential activation of events that lead to restoration of hepatic mass. During this process, other vital liver functions need to be preserved, such as ...
Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner
Eicosapentaenoic acid (EPA) has garnered attention after the success of the REDUCE-IT trial, which contradicted previous conclusions on EPA for cardiovascular disease risk. Here we first investigated EPA's preventative ...
Cardiac fibroblasts and mechanosensation in heart development, health and disease
The term 'mechanosensation' describes the capacity of cells to translate mechanical stimuli into the coordinated regulation of intracellular signals, cellular function, gene expression and epigenetic programming. This ...
Relevance of CD6-Mediated interactions in the regulation of peripheral T-Cell responses and tolerance
The CD6 lymphocyte receptor has been involved in the pathophysiology of different autoimmune disorders and is now considered a feasible target for their treatment. In vitro data show the relevance of CD6 in the stabilization ...
