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Biomedicina: Envíos recientes

Mostrando ítems 701-720 de 779

    Cholesterol regulates Syntaxin 6 trafficking at the TGN-endosomal boundaries 

    Reverter Martín, Meritxell; Rentero Alfonso, Carles; García Melero, Ana; Hoque, Monira; Vilà de Muga, Sandra; Álvarez-Guaita, Anna; Conway, James; Wood, Peta; Cairns, Rose; Lykopoulou, Lila; Grinberg Vaisman, Daniel Raúl; Vilageliu i Arqués, Lluïsa; Bosch i Rodríguez, Marta; Heeren, Joerg; Blasi Cabús, Joan; Timpson, Paul; Pol i Sorolla, Albert; Tebar Ramon, Francesc; Murray, Rachael Z.; Grewal, Thomas (Fecha de publicación: 2014-05-21)

    Inhibition of cholesterol export from late endosomes causes cellular cholesterol imbalance, including cholesterol depletion in the trans-Golgi network (TGN). Here, using Chinese hamster ovary (CHO) Niemann-Pick type C1 ...

    Huntington's disease brain-derived small RNAs recapitulate associated neuropathology in wild-type mice 

    Creus Muncunill, Jordi; Guisado Corcoll, Anna; Venturi, Verónica; Pantano, Lorena; Escaramís Babiano, Geòrgia; Gardia de Herreros, Marta; Solanguren-Beascoa, Maria; Gámez Valero, Ana; Navarrete, Cristina; Masana Nadal, Mercè; Llorens Torres, Franc; Diaz-Lucena, Daniela; Pérez Navarro, Esther; Martí Puig, Eulàlia (Fecha de publicación: 2021-03-15)

    Progressive motor alterations and selective death of striatal medium spiny neurons (MSNs) are key pathological hallmarks of Huntington's disease (HD), a neurodegenerative condition caused by a CAG trinucleotide repeat ...

    H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells 

    Fernández, Agustín F.; Bayón, Gustavo F.; Urdinguio, Rocío G.; Toraño, Estela G.; García, María G.; Carella, Antonella; Petrus-Reurer, Sandra; Ferrero, Cecilia; Martínez Camblor, Pablo; Cubillo, Isabel; García Castro, Javier; Delgado Calle, Jesús; Pérez-Campo, Flor M.; Riancho, José A.; Bueno, Clara; Menéndez Buján, Pablo; Mentink, Anouk; Mareschi, Katia; Claire, Fabian; Fagnani, Corrado; Medda, Emanuela; Toccaceli, Virgilia; Brescianini, Sonia; Moran, Sebastian; Esteller, Manel; Stolzing, Alexandra; Boer, Jan de; Nistico, Lorenza; Stazi, Maria A.; Fraga, Mario F. (Fecha de publicación: 2020-12-17)

    In differentiated cells, aging is associated with hypermethylation of DNA regions enriched in repressive histone post-translational modifications. However, the chromatin marks associated with changes in DNA methylation in ...

    A Bayesian cost-effectiveness analysis of a telemedicine-based strategy for the management of sleep apnoea: a multicentre randomised controlled trial 

    Isetta, Valentina; Negrín, Miguel A.; Monasterio Ponsa, Carmen; Masa, Juan F.; Feu, Nuria; Álvarez, Ainhoa; Campos Rodríguez, Francisco; Ruiz, Concepción; Abad, Jorge; Vázquez Polo, Francisco J.; Farré Ventura, Ramon; Galdeano Lozano, Marina; Lloberes, Patricia; Embid, Cristina; Peña, Mónica de la; Puertas, Javier; Dalmases Cleries, Mireia; Salord, Neus; Corral, Jaime; Jurado, Bernabé; León, Carmen; Egea, Carlos; Muñoz, Aida; Parra Ordaz, Olga; Cambrodi, Roser; Martel-Escobar, María; Arqué, Meritxell; Montserrat Canal, José Ma.; Spanish Sleep Network (Fecha de publicación: 2016-11-07)

    BACKGROUND: Compliance with continuous positive airway pressure (CPAP) therapy is essential in patients with obstructive sleep apnoea (OSA), but adequate control is not always possible. This is clinically important because ...

    Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function 

    Reverter Martín, Meritxell; Rentero Alfonso, Carles; Vilà de Muga, Sandra; Álvarez-Guaita, Anna; Mulay, Vishwaroop; Wood, Peta; Monastyrskaya, Katia; Pol i Sorolla, Albert; Tebar Ramon, Francesc; Blasi Cabús, Joan; Grewal, Thomas; Enrich Bastús, Carles; Cairns, Rose (Fecha de publicación: 2012-02-02)

    Cholesterol regulates plasma membrane (PM) association and functioning of syntaxin-4 and soluble N-ethylmaleimide-sensitive fusion protein 23 (SNAP23) in the secretory pathway. However, the molecular mechanism and cellular ...

    Comprehensive analysis of GABAA-A1R developmental alterations in Rett Syndrome: setting the focus for therapeutic targets in the time frame of the disease 

    Oyarzabal, Alfonso; Xiol Viñas, Clara; Castells, Aina-Alba; Grau, Cristina; O'Callaghan, Mar; Fernàndez, Guerau; Alcántara Horrillo, Soledad; Pineda Marfà, Mercè; Armstrong i Morón, Judith; Altafaj, Xavier; García Cazorla, Àngels (Fecha de publicación: 2020-12-11)

    Rett syndrome, a serious neurodevelopmental disorder, has been associated with an altered expression of different synaptic-related proteins and aberrant glutamatergic and γ-aminobutyric acid (GABA)ergic neurotransmission. ...

    Extracellular NK histones promote immune cell anti-tumor activity by inducing cell clusters through binding to CD138 receptor. 

    Martín-Antonio, Beatriz; Suñé, Guillermo; Najjar, A.; Perez-Amill, L.; Antoñana Vildosola, Asier; Castellà Castellà, Maria; León, S.; Velasco de Andrés, María; Lozano Soto, Francisco; Lozano Garcia, Ester; Bueno, Clara; Estanyol i Ullate, Josep Maria; Muñoz Pinedo, Cristina; Robinson, S.N.; Urbano Ispizua, Álvaro (Fecha de publicación: 2020-06-17)

    BACKGROUND: Natural killer (NK) cells are important anti-tumor cells of our innate immune system. Their anti-cancer activity is mediated through interaction of a wide array of activating and inhibitory receptors with their ...

    Lack of a 5.9 kDa peptide C-terminal fragment of fibrinogen α chain precedes fibrosis progression in patients with liver disease 

    Marfà Bruix, Santiago; Crespo Conde, Gonzalo; Reichenbach Marinkovic, Vedrana; Forns, Xavier; Casals Mercadal, Gregori; Morales Ruiz, Manuel; Navasa, Miquel; Jiménez Povedano, Wladimiro (Fecha de publicación: 2017-11-08)

    Early detection of fibrosis progression is of major relevance for the diagnosis and management of patients with liver disease. This study was designed to find non-invasive biomarkers for fibrosis in a clinical context where ...

    Distinct functional activity of the precuneus and posterior cingulate cortex during encoding in the preclinical stage of Alzheimer's Disease 

    Rami González, Lorena; Sala Llonch, Roser; Solé Padullés, Cristina; Fortea Ormaechea, Juan; Olives, Jaume; Lladó Plarrumaní, Albert; Peña-Gómez, Cleofé; Balasa, Mircea; Bosch, Beatriz; Antonell Boixader, Anna, 1978-; Sánchez del Valle Díaz, Raquel; Bartrés Faz, David; Molinuevo, José Luis (Fecha de publicación: 2020-05-29)

    In this study functional magnetic resonance imaging (fMRI) is used to investigate the functional brain activation pattern in the preclinical stage of AD (pre-AD) subjects during a visual encoding memory task. Thirty subjects, ...

    Hierarchical cluster analysis of multimodal imaging data identifies brain atrophy and cognitive patterns in Parkinson's disease 

    Inguanzo, Anna; Sala Llonch, Roser; Segura i Fàbregas, Bàrbara; Erostarbe, H.; Abós, Alexandra; Campabadal Delgado, Anna; Uribe, Carme; Baggio, Hugo César; Compta, Yaroslau; Martí Domènech, Ma. Josep; Valldeoriola Serra, Francesc; Bargalló Alabart, Núria; Junqué i Plaja, Carme, 1955- (Fecha de publicación: 2021-03-09)

    Background: Parkinson's disease (PD) is a heterogeneous condition. Cluster analysis based on cortical thickness has been used to define distinct patterns of brain atrophy in PD. However, the potential of other neuroimaging ...

    Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study 

    Peremiquel Trillas, Paula; Benavente, Yolanda; Martín Bustamante, Mayte; Casabonne, Delphine; Pérez Gómez, Beatriz; Gómez Acebo, Inés; Oliete Canela, Anna; Diéguez Rodríguez, Marta; Tusquets, Ignasi; Amiano, Pilar; Mengual Brichs, Lourdes; Ardanaz, Eva; Capelo Álvarez, Rocío; Molina de la Torre, Antonio José; Salas Trejo, Dolores; Fernández Tardón, Guillermo; Lope, Virginia; Jimenez Moleon, Jose J.; Marcos Gragera, Rafael; Dierssen Sotos, Trinidad; Azpiri, Mikel; Muñoz, Montse; Guevara, Marcela; Fernández Villa, Tania; Molina Barceló, Ana; Aragonès Sanz, Núria; Pollán, Marina; Castaño-Vinyals, Gemma; Alguacil, Juan; Kogevinas, Manolis; Sanjosé Llongueras, Silvia de; Costas, Laura (Fecha de publicación: 2020-11-11)

    Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the ...

    Platelet-activating factor causes ventilation-perfusion mismatch in humans 

    Rodríguez-Roisin, Robert; Félez Flor, Miguel Ángel; Chung, K. Fan, 1951-; Barberà i Mir, Joan Albert; Wagner, P. D. (Peter D.); Cobos Carbó, Albert; Barnes, Peter J.; Roca Torrent, Josep (Fecha de publicación: 2009-05-14)

    We hypothesized that platelet-activating factor (PAF), a potent inflammatory mediator, could induce gas exchange abnormalities in normal humans. To this end, the effect of aerosolized PAF (2 mg/ml solution; 24 micrograms) ...

    Akt-mediated FoxO1 inhibition is required for liver regeneration 

    Pauta, Montse; Rotllan, Noemi; Fernández Hernando, Ana; Langhi, Cedric; Ribera Sabaté, Jordi; Boix i Ferrero, Loreto; Bruix Tudó, Jordi; Jiménez Povedano, Wladimiro; Duarez, Yajaira; Ford, David A.; Baldán, Morris J.; Bimbaum, Morris J.; Morales Ruiz, Manuel; Fernández Hernando, Carlos (Fecha de publicación: 2021-01-20)

    Understanding the hepatic regenerative process has clinical interest as the effectiveness of many treatments for chronic liver diseases is conditioned by efficient liver regeneration. Experimental evidence points to the ...

    Role of Cyclooxygenase-2 on Intermittent Hypoxia-Induced Lung Tumor Malignancy in a Mouse Model of Sleep Apnea 

    Campillo, Noelia; Torres, Marta; Vilaseca, Antoni; Nonaka, Paula Naomi; Gozal, David; Roca i Ferrer, Jordi; Picado Vallés, César; Montserrat Canal, José Ma.; Farré Ventura, Ramon; Navajas Navarro, Daniel; Almendros López, Isaac (Fecha de publicación: 2018-04-10)

    An adverse role for obstructive sleep apnea (OSA) in cancer epidemiology and outcomes has recently emerged from clinical and animal studies. In animals, intermittent hypoxia (IH) mimicking OSA promotes tumor malignancy ...

    Alzheimer's disease mutant mice exhibit reduced brain tissue stiffness compared to wild-type mice in both normoxia and following intermittent hypoxia mimicking sleep apnea 

    Menal, Maria Jose; Jorba, Ignasi; Torres, Marta; Montserrat Canal, José Ma.; Gozal, David; Colell Riera, Anna; Pinol Ripoll, Gerard; Navajas Navarro, Daniel; Almendros López, Isaac; Farré Ventura, Ramon (Fecha de publicación: 2019-12-11)

    Background: Evidence from patients and animal models suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer's disease (AD) and that AD is associated with reduced brain tissue stiffness.Aim: To ...

    White matter integrity related to functional working memory networks in traumatic brain injury 

    Palacios, Eva M.; Sala Llonch, Roser; Junqué i Plaja, Carme, 1955-; Roig-Rovira, Teresa; Tormos, José María; Bargalló Alabart, Núria; Vendrell i Gómez, Pere (Fecha de publicación: 2020-05-29)

    Objective: This study explores the functional and structural patterns of connectivity underlying working memory impairment after severe traumatic axonal injury. Methods: We performed an fMRI n-back task and acquired diffusion ...

    Specific small-RNA signatures in the amygdala at premotor and motor stages of Parkinson's disease revealed by deep sequencing analysis 

    Pantano, Lorena; Friedlaender, Marc R.; Escaramís Babiano, Geòrgia; Lizano, Esther; Pallarès Albanell, Joan; Ferrer, Isidro (Ferrer Abizanda); Estivill, Xavier, 1955-; Martí Puig, Eulàlia (Fecha de publicación: 2019-07-16)

    Motivation: Most computational tools for small non-coding RNAs (sRNA) sequencing data analysis focus in microRNAs (miRNAs), overlooking other types of sRNAs that show multi-mapping hits. Here, we have developed a pipeline ...

    Exploring Autophagy In Drosophila 

    Lörincz, Péter; Mauvezin, Caroline; Juhász, Gábor (Fecha de publicación: 2018-09-04)

    Autophagy is a catabolic process in eukaryotic cells promoting bulk or selective degradation of cellular components within lysosomes. In recent decades, several model systems were utilized to dissect the molecular machinery ...

    Inherited functional variants of the lymphocyte receptor CD5 influence melanoma survival 

    Potrony Mateu, Míriam; Carreras Margalef, Esther; Aranda, Fernando; Zimmer, Lisa; Puig Butillé, Joan Anton; Tell Martí, Gemma; Armiger Borràs, Noelia; Sucker, Antje; Gimenez-Xavier, Pol; Martínez-Florensa, Mario; Carrera Álvarez, Cristina; Malvehy, J. (Josep); Schadendorf, Dirk; Puig i Sardà, Susana; Lozano Soto, Francisco (Fecha de publicación: 2017-02-20)

    Despite the recent progress in treatment options, malignant melanoma remains a deadly disease. Besides therapy, inherited factors might modulate clinical outcome, explaining in part widely varying survival rates. T-cell ...

    Neuropsychological Impairment in Post-COVID condition individuals with and without cognitive complaints 

    Ariza González, Mar; Cano Marco, Neus; Segura i Fàbregas, Bàrbara; Adan Puig, Ana; Bargalló Alabart, Núria; Caldú i Ferrús, Xavier; Campabadal Delgado, Anna; Jurado, Ma. Ángeles (María Ángeles); Mataró Serrat, Maria; Pueyo Benito, Roser; Sala Llonch, Roser; Barrué, Cristian; Béjar, Javier; Cortés, Claudio Ulises; Junqué i Plaja, Carme, 1955-; Garolera i Freixa, Maite (Fecha de publicación: 2024-04-08)

    One of the most prevalent symptoms of post-COVID condition is cognitive impairment, which results in a significant degree of disability and low quality of life. In studies with large sample sizes, attention, memory, and ...