Biomedicina: Envíos recientes
Mostrando ítems 341-360 de 779
Characterization of Novel P-Selectin Targeted Complement Inhibitors in Murine Models of Hindlimb Injury and Transplantation
The complement system has long been recognized as a potential druggable target for a variety of inflammatory conditions. Very few complement inhibitors have been approved for clinical use, but a great number are in clinical ...
Systemic inflammation and acute-on-chronic liver failure: too much, not enough
ACLF is a specific, but complex and multifactorial form of acute decompensation of cirrhosis and is characterized by an extraordinary dynamic natural course, rapidly evolving organ failure, and high short-term mortality. ...
Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with TVIBLINDI
Understanding complex, organ-level single-cell datasets represents a formidable interdisciplinary challenge. This study aims to describe developmental trajectories of thymocytes and mature T cells. We developed tviblindi, ...
Slamf6 negatively regulates autoimmunity
The nine SLAM family (Slamf) receptors are positive or negative regulators of adaptive and innate immune responses, and of several autoimmune diseases. Here we report that the transfer of Slamf6-/- B6 CD4+ T cells into ...
MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence
Large cell carcinoma (LCC) is a rare and aggressive lung cancer subtype with poor prognosis and no targeted therapies. Tumor-associated fibroblasts (TAFs) derived from LCC tumors exhibit premature senescence, and coculture ...
Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration
Using genetic tools, here we describe that Ikzf1 is specifically expressed in the adult microglia in brain regions such as cortex and hippocampus. By characterizing the Ikzf1 deficient mice, we observed that these mice ...
p27Kip1 regulates alpha-synuclein expression
Alpha-synuclein (α-SYN) is the main component of anomalous protein aggregates (Lewy bodies) that play a crucial role in several neurodegenerative diseases (synucleinopathies) like Parkinson's disease and multiple system ...
Single cell RNA sequencing identifies IGFBP5 and QKI as ciliated epithelial cell genes associated with severe COPD
Background: Whole lung tissue transcriptomic profling studies in chronic obstructive pulmonary disease (COPD) have led to the identifcation of several genes associated with the severity of airfow limitation and/or the ...
Phospho-RNA-Seq highlights specific small RNA profiles in plasma extracellular vesicles
Small RNAs (sRNAs) are bioactive molecules that can be detected in biofluids, reflecting physiological and pathological states. In plasma, sRNAs are found within extracellular vesicles (EVs) and in extravesicular compartments, ...
Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma
Mantle cell lymphoma (MCL) is considered one of the most challenging lymphoma, with limited responses to current therapies. Acadesine, a nucleoside analogue has shown antitumoral effects in different preclinical cancer ...
Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models
Conformational changes in disease-associated or mutant proteins represent a key pathological aspect of Huntington's disease (HD) and other protein misfolding diseases. Using immunoassays and biophysical approaches, we and ...
Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington's disease mice.
N6-methyladenosine (m6A) regulates many aspects of RNA metabolism and is involved in learning and memory processes. Yet, the impact of a dysregulation of post-transcriptional m6A editing on synaptic impairments in ...
Intermittent hypoxia mimicking sleep apnea increases passive stiffness of myocardial extracellular matrix. A multiscale study
Background: Tissue hypoxia-reoxygenation characterizes obstructive sleep apnea (OSA), a very prevalent respiratory disease associated with increased cardiovascular morbidity and mortality. Experimental studies indicate ...
Conserved bacterial-binding peptides of the scavenger-like lymphocyte receptor CD6 protect from mouse experimental sepsis
Sepsis is an unmet clinical need constituting one of the most important causes of death worldwide, a fact aggravated by the appearance of multidrug resistant strains due to indiscriminate use of antibiotics. Host innate ...
Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters
The purpose of this study was to determine and compare thigh muscle volumes (MVs), and sprint mechanical properties and performance between male and female national-level sprinters. We also studied possible relationships ...
Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure.
Background and aims: Acute-on-chronic liver failure (ACLF) is a complication of cirrhosis characterized by multiple organ failure and high short-term mortality. The pathophysiology of ACLF involves elevated systemic ...
Beyond BMI: cardiometabolic measures as predictors of impulsivity and white matter changes in adolescents
Obesity is characterized by cardiometabolic and neurocognitive changes. However, how these two factors relate to each other in this population is unknown. We tested the association that cardiometabolic measures may have ...
Membrane tension controls adhesion positioning at the leading edge of cells
Cell migration is dependent on adhesion dynamics and actin cytoskeleton remodeling at the leading edge. These events may be physically constrained by the plasma membrane. Here, we show that the mechanical signal produced ...
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models
Huntington's disease is caused by an expanded polyglutamine repeat in the huntingtin protein (HTT), but the pathophysiological sequence of events that trigger synaptic failure and neuronal loss are not fully understood. ...
La utilización del Mini Clinical Evaluation Exercise (mini-CEX) en estudiantes de medicina
En los últimos años se recomienda el uso de instrumentos que evalúen la adquisición de habilidades clínicas en el contexto de la práctica clínica. Entre los instrumentos más recomendados se encuentra el Mini Clinical ...
