Biomedicina: Enviaments recents
Ara mostrant els elements 361-380 de 779
Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters
The purpose of this study was to determine and compare thigh muscle volumes (MVs), and sprint mechanical properties and performance between male and female national-level sprinters. We also studied possible relationships ...
Distinct immunometabolic signatures in circulating immune cells define disease outcome in acute-on-chronic liver failure.
Background and aims: Acute-on-chronic liver failure (ACLF) is a complication of cirrhosis characterized by multiple organ failure and high short-term mortality. The pathophysiology of ACLF involves elevated systemic ...
Beyond BMI: cardiometabolic measures as predictors of impulsivity and white matter changes in adolescents
Obesity is characterized by cardiometabolic and neurocognitive changes. However, how these two factors relate to each other in this population is unknown. We tested the association that cardiometabolic measures may have ...
Membrane tension controls adhesion positioning at the leading edge of cells
Cell migration is dependent on adhesion dynamics and actin cytoskeleton remodeling at the leading edge. These events may be physically constrained by the plasma membrane. Here, we show that the mechanical signal produced ...
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models
Huntington's disease is caused by an expanded polyglutamine repeat in the huntingtin protein (HTT), but the pathophysiological sequence of events that trigger synaptic failure and neuronal loss are not fully understood. ...
La utilización del Mini Clinical Evaluation Exercise (mini-CEX) en estudiantes de medicina
En los últimos años se recomienda el uso de instrumentos que evalúen la adquisición de habilidades clínicas en el contexto de la práctica clínica. Entre los instrumentos más recomendados se encuentra el Mini Clinical ...
Open-source, low-cost, app-driven internet of things approach to facilitate respiratory oscillometry at home and in developing countries
This work provides a proof-of concept of the feasibility of a novel telemetric approach in oscillometry. As the aim was not to produce a final, commercially available setting (e.g.no effort was paid to optimize graphic ...
Lack of Annexin A6 exacerbates liver dysfunction and reduces lifespan of Niemann-Pick type C protein-deficient mice
Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized by cholesterol accumulation caused by loss-of-function mutations in the Npc1 gene. NPC disease primarily affects the brain, causing neuronal ...
Meridianins and Lignarenone B as Potential GSK3β Inhibitors and Inductors of Structural Neuronal Plasticity
Glycogen Synthase Kinase 3 (GSK3) is an essential protein, with a relevant role in many diseases such as diabetes, cancer and neurodegenerative disorders. Particularly, the isoform GSK3β is related to pathologies such as ...
Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene
Background: Phosphodiesterases are an important protein family that catalyse the hydrolysis of cyclic nucleotide monophosphates (cAMP and cGMP), second intracellular messengers responsible for transducing a variety of ...
KATP channel expression and genetic polymorphisms associated with progression and survival in amyotrophic lateral sclerosis.
The ATP-sensitive potassium (KATP) channel directly regulates the microglia-mediated inflammatory response following CNS injury. To determine the putative role of the KATP channel in amyotrophic lateral sclerosis (ALS) ...
Biomechanical Response of Lung Epithelial Cells to Iron Oxide and Titanium Dioxide Nanoparticles
Increasing evidence shows that lungs can be damaged by inhalation of nanoparticles (NPs) at environmental and occupational settings. Recent findings have associated the exposure to iron oxide (Fe2O3) and titanium dioxide ...
A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease mice
Huntington's disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families. The ...
Aortic remodelling induced by obstructive apneas is normalized with mesenchymal stem cells infusion
Obstructive sleep apnea syndrome (OSA) promotes aortic dilatation, increased stiffness and accelerated atherosclerosis, but the mechanisms of vascular remodelling are not known. We aimed to assess vascular remodelling, its ...
Leukocytes from obese individuals exhibit an impaired SPM signature
Specialized proresolving mediators (SPMs) biosynthesized from docosahexaenoic acids (DHAs) including resolvins (Rvs), protectins, and maresins are potent endogenous autacoids that actively resolve inflammation, protect ...
Development of an epidermal growth factor derivative with EGFR blocking activity.
The members of the epidermal growth factor (EGF)/ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying new molecules that ...
Novel Regulation of the Synthesis of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus
The regulation of AMPA-type receptor (AMPAR) abundance in the postsynaptic membrane is an important mechanism involved in learning and memory formation. Recent data suggest that one of the constituents of the AMPAR complex ...
Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells.
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger ...
Hacia una nueva forma de evaluación en educación médica: la evaluación programática
Hace ahora seis años, desde estas mismas páginas, en un editorial sobre el proceso de Bolonia [1], el profesor Albert Oriol afirmaba que la evaluación de las competencias constituía un gran reto para las universidades ...
CAR-T cells targeting CCR9 and CD1a for the treatment of T cell acute lymphoblastic leukemia.
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy characterized by high rates of induction failure and relapse, and effective targeted immunotherapies are lacking. Despite promising clinical progress ...
