Biomedicina: Enviaments recents
Ara mostrant els elements 601-620 de 779
Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis
The potassium channel Kv1.3 plays roles in immunity, neuronal development and sensory discrimination. Regulation of Kv1.3 by kinase signaling has been studied. In this context, EGF binds to specific receptors (EGFR) and ...
When GETomics meets aging and exercise in COPD
The term GETomics has been recently proposed to illustrate that human health and disease are actually the final outcome of many dynamic, interacting and cumulative gene (G) - environment (E) interactions that occur through ...
Don’t Take Away My P: Phosphatases as Therapeutic Targets in Huntington’s Disease
The molecular bases that account for the preferential neurodegeneration of striatal mediumsized spiny neurons (MSNs) in Huntington’s Disease (HD) are still unknown, and different mechanisms have been proposed to contribute ...
Andronet News. Summar 2023
Since most of us have just returned from the summer break, this edition will be shorter than usual. The main item is the brief report from our main event held in June in conjunction with the 22nd European Testis Workshop ...
Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis
BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) is a syndrome that occurs in cirrhosis characterized by organ failure(s) and high mortality rate. There are no biomarkers of ACLF. The LCN2 gene and its product, ...
Neuropilin-2 upregulation by stromal TGFβ1 induces lung disseminated tumor cells dormancy escape and promotes metastasis outgrowth
Metastasis is the main cause of death from solid tumors. Therefore, identifying the mechanisms that govern metastatic growth poses a major biomedical challenge. Tumor microenvironment signals regulate the fate and survival ...
Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management
Background and hypothesis: Heterogeneity in clinical manifestations and disease progression in Chronic Obstructive Pulmonary Disease (COPD) lead to consequences for patient health risk assessment, stratification and ...
Reversible effects of the SARS-CoV-2 on semen parameters
Despite that the SARS-CoV-2 pandemic has been controlled, it has affected a large proportion of the population, raising some concerns about potential sequelae in men at reproductive age. To contribute to the clarification ...
Reciprocal Negative Cross-Talk between Liver X Receptors (LXRs) and STAT1: Effects on IFN-gamma-Induced Inflammatory Responses and LXR-Dependent Gene Expression
Liver X receptors (LXRs) exert key functions in lipid homeostasis and in control of inflammation. In this study we have explored the impact of LXR activation on the macrophage response to the endogenous inflammatory cytokine ...
El mini-CEX como instrumento de evaluación de la competencia clínica. Un estudio piloto en estudiantes de Medicina.
Introduction. The evaluation of clinical skills is an important part of the medical training. The present article describes the results of a pilot study that was carried out to analyze the feasibility of the implementation ...
Effect of high mobility group nonhistone proteins HMG-20 (ubiquitin) and HMG-17 on histone deacetylase activity assayed in vitro
We have used a method previously described by Reeves and Candido (1) to partially release histone deacetylase from cell nuclei together with putative regulators of the enzyme. Histone deacetylase released from testis cell ...
Neuropsychological Impairment in Post-COVID condition individuals with and without cognitive complaints
One of the most prevalent symptoms of post-COVID condition is cognitive impairment, which results in a significant degree of disability and low quality of life. In studies with large sample sizes, attention, memory, and ...
In vivo evaluation of the dopaminergic neurotransmission system using [123 I]FP-CIT SPECT in 6-OHDA lesioned rats
The 6-hydroxydopamine (6-OHDA) rodent model of Parkinson's disease (PD) has been used to evaluate the nigrostriatal pathway. The aim of this work was to explore the relationship between the degree of 6-OHDA-induced ...
The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo.
BACKGROUND: Knowledge of the proteomic composition of the gametes is essential to understand reproductive functions. Most of the sperm proteins are related to spermatogenesis and sperm function, but less abundant protein ...
Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux
Caveolin-1 (Cav1), a structural protein required for the formation of invaginated membrane domains known as caveolae, has been implicated in cholesterol trafficking and homeostasis. Here we investigated the contribution ...
Cell compression - relevance, mechanotransduction mechanisms and tools
From border cell migration during Drosophila embryogenesis to solid stresses inside tumors, cells are often compressed during physiological and pathological processes, triggering major cell responses. Cell compression can ...
Andronet News. Spring 2024
It is my pleasure to announce a change in the Science Communication Coordination Committee. Ewa Rajpert-De Meyts and Sandra Laurentino swapped their positions, so now Sandra is the Coordinator. Sandra has proven a very ...
Andronet. Winter 2023/2024
After a nice Holiday Season at the end of 2023, we are now looking forward to new activities in the spring. Note that ANDRONET will support several short-term scientific visits for collaborating researchers or clinical ...
A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity
Here we report the characterization of 17T2, a SARS-CoV-2 pan-neutralizing human monoclonal antibody isolated from a COVID-19 convalescent individual infected during the first pandemic wave. 17T2 is a class 1 VH1-58/κ3-20 ...
Follow-Up After Myocardial Infarction to Explore the Stability of Arrhythmogenic Substrate: The Footprint Study.
Objectives This study aimed to characterize the long-term scar remodeling process after an acute myocardial infarction (AMI) and the underlying scar-related arrhythmogenic substrate using serial late gadolinium enhancement ...
