Biomedicina: Enviaments recents
Ara mostrant els elements 621-640 de 779
Biomedical research in a digital health framework
This article describes a Digital Health Framework (DHF), benefitting from the lessons learnt during the three-year life span of the FP7 Synergy-COPD project. The DHF aims to embrace the emerging requirements--data and ...
Lamin B1 and nuclear morphology in peripheral cells as new potential biomarkers to follow treatment response in Huntington's disease
In neurodegenerative diseases, neuronal dysfunction and degeneration start many years before the emergence of clinical symptoms. An important goal to advance in their knowledge and treatment is the identification of ...
Improved image quality in pinhole SPECT by accurate modeling of the point spread function in low magnification systems
It is well-known that in pinhole SPECT (single-photon-emission computed tomography), iterative reconstruction methods including accurate estimations of the system response matrix can lead to submillimeter spatial resolution. ...
Modeling and subtleties of K-Ras and Calmodulin interaction
K-Ras, one of the most common small GTPases of the cell, still presents many riddles, despite the intense efforts to unveil its mysteries. Such is the case of its interaction with Calmodulin, a small acidic protein known ...
Andronet News. Summar 2022
This tool is meant as one of the several ways of communication and will secure that updates or important information drop directly into your mailbox. The frequency and content of the newsletters will be evolving in ...
Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis
Brown adipose tissue (BAT) thermogenesis affects energy balance, and thereby it has the potential to induce weight loss and to prevent obesity. Here, we document a macroautophagic/autophagic-dependent mechanism of peroxisome ...
Investigation of CCL18 and A1AT as potential urinary biomarkers for bladder cancer detection
BACKGROUND: In this study, we further investigated the association of two biomarkers, CCL18 and A1AT, with bladder cancer (BCa) and evaluated the influence of potentially confounding factors in an experimental model. ...
Increased translation in adult mouse striatum is sufficient to induce motor dysfunction
Protein synthesis is a process finely regulated in all cell types but specially in neurons as they need rapid changes in protein concentration for synaptic plasticity. Alterations in translation rates have been shown in ...
Updated Toolbox for Assessing Neuronal Network Reconstruction after Cell Therapy
Cell therapy has proven to be a promising treatment for a range of neurological disorders, including Parkinson Disease, drug-resistant epilepsy, and stroke, by restoring function after brain damage. Nevertheless, evaluating ...
Andronet News. Summar 2024
With Summer drawing to an end, our Action had its main event of the year. At the beginning of September, we gathered in an unusually sunny and warm Stockholm to attend the European Congress of Andrology (ECA2024), ...
Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies
BACKGROUND: Mutations in the gene encoding thymidine kinase 2 (TK2) result in the myopathic form of mitochondrial DNA depletion syndrome which is a mitochondrial encephalomyopathy presenting in children. In order to unveil ...
Palmitoylcarnitine impairs immunity in decompensated cirrhosis
Background & aims: In patients with cirrhosis, acute decompensation (AD) correlates with a hyperinflammatory state driven by mitochondrial dysfunction, which is a significant factor in the progression toward acute-on-chronic ...
Prognostic microRNAs in upper tract urothelial carcinoma: multicenter and international validation study
Objective: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients.Patients and Methods: Multicenter, international and retrospective ...
Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer's Disease
Glycogen synthase kinase 3β (GSK3β) is a core protein, with a relevant role in many neurodegenerative disorders including Alzheimer's disease. The enzyme has been largely studied as a potential therapeutic target for several ...
SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.
Background SARS-CoV-2 infection during pregnancy is known to be associated with poor pregnancy outcomes, including pre-eclampsia (PE), prematurity, perinatal and maternal mortality. Data on the burden of SARS-CoV-2 infection ...
Liver X receptors and inflammatory-induced C/EBPβ selectively cooperate to control CD38 transcription
Introduction: Macrophages abundantly express liver X receptors (LXRs), which are ligand-dependent transcription factors and sensors of several cholesterol metabolites. In response to agonists, LXRs promote the expression ...
Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts
We have shown previously (Villalonga, P., López- Alcalá, C., Bosch, M., Chiloeches, A., Rocamora, N., Gil, J., Marais, R., Marshall, C. J., Bachs, O., and Agell, N. (2001) Mol. Cell. Biol. 21, 7345-7354) that calmodulin ...
Andronet News. Spring 2023
Our main annual event is quickly approaching - we are looking forward to the ANDRONET Workshop and the Managing Committee Meeting which will be held in June in conjunction with the 22nd European Testis Workshop (ETW2023), ...
Characterisation of the gut-lung axis microbiome in clinically stable patients with chronic obstructive pulmonary disease.
Background Airway and gut dysbiosis have been reported in Chronic Obstructive Pulmonary Disease (COPD); however, their relationship and association with clinical features remain poorly understood. We aimed to characterise ...
Ribonucleoprotein HNRNPA2B1 interacts with and regulates oncogenic KRAS in Pancreatic Ductal Adenocarcinoma Cells.
BACKGROUND & AIMS: Development of pancreatic ductal adenocarcinoma (PDAC) involves activation of c-Ki-ras2 Kirsten rat sarcoma oncogene homolog (KRAS) signaling, but little is known about the roles of proteins that regulate ...
