Biomedicina: Enviaments recents
Ara mostrant els elements 301-320 de 779
Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes
Major depressive disorder (MDD) is a common disorder with a variety of symptoms including mood alterations, anhedonia, sleep and appetite disorders, and cognitive disturbances. Stressful life events are among the strongest ...
Proteomics and the genetics of sperm chromatin condensation
Spermatogenesis involves extremely marked cellular, genetic and chromatin changes resulting in the generation of the highly specialized sperm cell. Proteomics allows the identification of the proteins that compose the ...
El 'Real Decreto de Troncalidad' de la formación especializada
Una vez la troncalidad ha dejado de ser un proyecto para convertirse en un RD tangible en el papel del BOE, la Fundación Educación Médica (FEM)considera oportuno y pertinente reflexionar sobre qué es la troncalidad, para ...
Guía para la definición de los perfiles competenciales profesionales
La declaración de Bolonia de 1999 ha comportado diferentes cambios y retos en el mundo de la educación médica. Entre ellos, uno de los más relevantes es la elaboración de programas formativos basados en competencias ...
p75NTR in Huntington's disease: beyond the basal ganglia
Huntington’s disease (HD) is a fatal neurodegenerative disorder with a characteristic phenotype including chorea and dystonia, uncoordinated fine movements, cognitive decline and psychiatric disturbances. Even though ...
Multifaceted Effects of Soluble Human CD6 in Experimental Cancer Models
Background: CD6 is a lymphocyte surface co-receptor physically associated with the T-cell receptor (TCR)/CD3 complex at the center of the immunological synapse. There, CD6 assists in cell-to-cell contact stabilization and ...
Parametric modeling of mechanical effects on circadian oscillators
Circadian rhythms are archetypal examples of nonlinear oscillations. While these oscillations are usually attributed to circuits of biochemical interactions among clock genes and proteins, recent experimental studies reveal ...
'In vitro' Effect of Different Follicle¿Stimulating Hormone Preparations on Sertoli Cells: Toward a Personalized Treatment for Male Infertility
Follicle-stimulating hormone (FSH), a major regulator of spermatogenesis, has a crucial function in the development and function of the testis and it is extensively given as a fertility treatment to stimulate spermatogenesis. ...
Physical principles of membrane remodelling during cell mechanoadaptation
Biological processes in any physiological environment involve changes in cell shape, which must be accommodated by their physical envelope the bilayer membrane. However, the fundamental biophysical principles by which the ...
NPPB and ACAN, two novel SHOX2 transcription targets implicated in skeletal development
SHOX and SHOX2 transcription factors are highly homologous, with even identical homeodomains. Genetic alterations in SHOX result in two skeletal dysplasias; Léri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia ...
RTP801 is involved in mutant huntingtin-induced cell death
RTP801 expression is induced by cellular stress and has a pro-apoptotic function in non-proliferating differentiated cells such as neurons. In several neurodegenerative disorders, including Parkinson's disease and Alzheimer's ...
Differences in the thoracic aorta by region and sex in a murine model of Marfan Syndrome
Marfan syndrome (MFS) is a hereditary disorder of the connective tissue that causes life-threatening aortic aneurysm, which initiates at the aortic root and can progress into the ascending portion. However, analysis of ...
Allopurinol blocks aortic aneurysm in a mouse model of Marfan syndrome via reducing aortic oxidative stress
Background Increasing evidence indicates that redox stress participates in MFS aortopathy, though its mechanistic contribution is little known. We reported elevated reactive oxygen species (ROS) formation and NADPH oxidase ...
Neurotrophin receptor p75NTR mediates Huntington's disease-associated synaptic and memory dysfunction
Learning and memory deficits are early clinical manifestations of Huntington's disease (HD). These cognitive impairments have been mainly associated with frontostriatal HD pathology; however, compelling evidence provided ...
APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls
BACKGROUND: The APOE effect on Alzheimer Disease (AD) risk is stronger in women than in men but its mechanisms have not been established. We assessed the APOE-by-sex interaction on core CSF biomarkers, brain metabolism and ...
Plasma copeptin as biomarker of disease progression and prognosis in cirrhosis
BACKGROUND & AIMS: Research on vasopressin (AVP) in cirrhosis and its role in the assessment of prognosis has been hindered by the difficulty of measuring AVP levels accurately. Copeptin, a 39-aminoacid glycopeptide, is ...
Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity
Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder caused by an expanded CAG/polyglutamine repeat in the coding region of the huntingtin (htt) gene. Although HD is classically considered ...
Social memory and social patterns alterations in the absence of striatal-enriched protein tyrosine phosphatase
STriatal-Enriched protein tyrosine Phosphatase (STEP) is a neural-specific protein that opposes the development of synaptic strengthening and whose levels are altered in several neurodegenerative and psychiatric disorders. ...
El numerus clausus de las facultades de medicina. Criterios y responsabilidades en el número de admitidos y en su distribución
Este número de la revista FEM incluye la transcripción integra de la reciente declaración del Foro de la Profesión Médica de España que, bajo el título '¿Por qué numerus clausus en medicina?', desgrana una serie de cuestiones, ...
PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27Kip1
P27(Kip1) (p27) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Recently, a new function of p27 as transcriptional regulator has been reported. It has been shown that p27 regulates the expression ...
