Biologia Cel·lular, Fisiologia i Immunologia: Enviaments recents
Ara mostrant els elements 1-20 de 561
Effect of different types of supervised exercise programs on cardiorespiratory and muscular fitness, pain, fatigue, mental health and inflammatory and oxidative stress biomarkers in older patients with post-COVID-19 sequelae “EJerSA-COVID-19”: a randomized controlled trial.
Background: Many patients with COVID-19 present the so-called post-acute sequelae of COVID-19 such as fatigue, post-stress discomfort, dyspnea, headache, pain mental impairment, incapacity to perform daily physical tasks ...
Mitochondrial adaptation to diet and swimming activity in Gilthead Seabream: Improved nutritional efficiency.
Sustained exercise promotes growth in different fish species, and in gilthead seabream we have demonstrated that it improves nutrient use efficiency. This study assesses for differences in growth rate, tissue composition ...
Adult-specific Reelin expression alters striatal neuronal organization. Implications for neuropsychiatric disorders.
In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, ...
Capillary pruning couples tissue perfusion and oxygenation with cardiomyocyte maturation in the postnatal mouse heart
Introduction: Removal of poorly perfused capillaries by pruning contributes to remodeling the microvasculature to optimize oxygen and nutrient delivery. Blood flow drives this process by promoting the intravascular migration ...
Impact of ocean acidification on skeletal structures in gilthead sea bream (Sparus aurata): In vitro and in vivo studies
Ocean acidification is considered a significant risk to aquaculture, as it may adversely affect the growth and development of aquatic organisms. The effect of ocean acidification has been shown to impair the growth and ...
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function
Author approved manuscript attached
Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer's disease
Background: New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising ...
Immune-Derived Cardiac Autonomic Signatures: Predicting Autonomic Responses to Exercise from B-Cell Phenotypes
Objective: Aging affects both immune and autonomic regulation, yet their interaction remains poorly characterized. This study investigated how aging B-cell subpopulations, defined by CD21/CD11c expression, are associated ...
Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion
Introduction: Brain connectivity requires correct axonal guidance to drive axons to their appropriate targets. This process is orchestrated by guidance cues that exert attraction or repulsion to developing axons. However, ...
SILAC-based assessment of S-palmitoylated proteins in mammalian cells by metabolic labeling and click-chemistry
S-palmitoylation of cysteine residues is the only lipid-based posttranslational modification of proteins that is reversible and therefore has important implications in cellular function. S-palmitoylation has been associated ...
Editorial: The impact of lipid metabolism on cancer progression and metastasis
Recent advances in oncology, immunology, and metabolic medicine have increasingly positioned lipid metabolism as a central determinant of cancer initiation, progression, and therapeutic response. Across multiple domains, ...
Association of Physical Fitness and Anthropometric Parameters With Lung Function in 7-Year-Old Children
Purpose: Associations between health-related parameters and lung function remain unclear in childhood. The study aims toevaluate the relationship between physical fitness and anthropometric parameters with the lung function ...
Pressure, Vibration, and Percussion in Athletic Recovery: With Great Power ComesGreat Responsibility
Self-applied mechanical pressure on the body is instinctively performed by several mammals, such as camels, sheep, and horses. In recent years, humans have further sophisticated this behavior due to advances in engineering. ...
Morphofunctional characterization of the three main adipose tissue depots in rainbow trout (Oncorhynchus mykiss)
Visceral adipose tissue (VAT) is the primary fat reservoir and energy source in fish. Other relevant fat depots include subcutaneous adipose tissue (SAT), located under epithelial layers, and intramuscular adipose tissue ...
Lung diffusing capacity after different modalities of exercise at sea level and hypobaric simulated altitude of 4000 m
Introduction: Lung diffusion capacity of carbon monoxide (DLCO) provides a measure of gas transfer in the lungs, which increase in relation to exercise and decrease in the presence of lung interstitial disease. The aim of ...
Propuesta de doble rúbrica en la enseñanza online. Estrategias de evaluación universitaria. Modelo de doble rúbrica (d-rubric) adaptado a las nuevas metodologías en un sistema docente online.
El cambio de la docencia a un entorno online, ha provocado la necesidad de adaptar nuevas metodologías de evaluación. Este trabajo propone una metodología de doble rúbrica como método clave de evaluación, dónde tanto el ...
Effects of intermittent exposure to hypobaric hypoxia and cold on skeletal muscle regeneration: mitochondrial dynamics, protein oxidation and turnover
Muscle injuries and the subsequent regeneration events compromise muscle homeostasis at morphological, functional and molecular levels. Among the molecular alterations, those derived from the mitochondrial function are ...
JNK signaling and its impact on neural cell maturation and differentiation
C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase family, are significantly linked with neurological and neurodegenerative pathologies and cancer progression. However, JNKs serve key roles ...
New murine Niemann-Pick type C models bearing a pseudoexongenerating mutation recapitulate the main neurobehavioural and molecular features of the disease
Niemann-Pick disease type C (NPC) is a rare neurovisceral disease caused mainly by mutations in the NPC1 gene. This autosomal recessive lysosomal disorder is characterised by the defective lysosomal secretion of cholesterol ...
Dissociation from BiP and Retrotranslocation of Unassembled Immunoglobulin Light Chains Are Tightly Coupled to Proteasome Activity
Unassembled immunoglobulin light chains expressed by the mouse plasmacytoma cell line NS1 (KNS1) are degraded in vivo with a half-life of 50-60 min in a way that closely resembles endoplasmic reticulum (ER)-associated ...
