Articles publicats Departament de Ciències Mèdiques: Envíos recientes
Mostrando ítems 21-40 de 390
More Than Three Decades After Discovery of the Neuroprotective Effect of PACAP, What Is Still Preventing Its Clinical Use?
Discovered in 1989, pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with strong neuroprotective properties, as shown in various neurodegenerative preclinical models of Parkinson, Alzheimer, or ...
Repeated Administrations of Polyphenolic Extracts Prevent Chronic Reflexive and Non-Reflexive Neuropathic Pain Responses by Modulating Gliosis and CCL2-CCR2/CX3CL1-CX3CR1 Signaling in Spinal Cord-Injured Female Mice
Neuropathic pain after spinal cord injury lacks any effective treatments, often leading to chronic pain. This study tested whether the daily administration of fully characterized polyphenolic extracts from grape stalks and ...
Soluble receptors for advanced glycation endproducts are predictors of insulin sensitivity and affected by weight loss
Background Mice experiments have underscored the efficacy of pharmacological inhibition of advanced glycation endproducts (AGEs) through the use of soluble receptors for advanced glycation endproducts (sRAGE) in mitigating ...
Longitudinal Analysis of Placental IRS1 DNA Methylation and Childhood Obesity
Accumulating evidence suggests that the predisposition to metabolic diseases is established in utero through epigenomic modifications. However, it remains unclear whether childhood obesity results from preexisting epigenomic ...
Health-Related Quality of Life in Men with Fractures and Fear of Falling in General Population: A Cross-Sectional Study
Purpose: This study aims to assess how fractures and fear of falling affect health-related quality of life (HRQoL) in men (≥50 years) across different domains. Methods: Design: Observational study. Setting: Primary care. ...
Decoding Pulmonary Embolism: Pathophysiology, Diagnosis, and Treatment
Pulmonary Embolism (PE) is a life-threatening condition initiated by the presence of blood clots in the pulmonary arteries, leading to severe morbidity and mortality. Underlying mechanisms involve endothelial dysfunction, ...
Case Reports: full facial rejuvenation with definisse fillers
Background: Several known factors contribute to the visible signs of facial aging. Changes in dentition and bony architecture, facial fat loss, diminished dermal thickness, and loss of dermal and subcutaneous support ...
Subcutaneous Injection and brush application of ovalbumin-aluminum salt solution induces dermatitis-like changes in mice
Background: Intraperitoneal sensitization combined with topical and/or epicu- taneous treatment using an ovalbumin (OVA)-aluminum salt solution (OVA-AL) repre- sents a model for inducing atopic dermatitis (AD). However, ...
The solvent chosen for the manufacturing of electrospun polycaprolactone scaffolds influences cell behavior of lung cancer cells
The development of a trustworthy in vitro lung cancer model is essential to better understand the illness, find novel biomarkers, and establish new treatments. Polycaprolactone (PCL) electrospun nanofibers are a cost-effective ...
Application of the adverse outcome pathway to identify molecular changes in prenatal brain programming induced by IUGR: Discoveries after EGCG exposure
Following a multi-disciplinary approach integrating information from several experimental models we have collected new evidence supporting, expanding and redesigning the AOP 'Disrupted laminin/int-β1 interaction leading ...
Case Reports on hand prejuvenation: clinical outcomes in middle-aged women with hyaluronic acid filler plus lidocaine
Background: Hand rejuvenation with hyaluronic acid filler injections is gaining more attention for its ability to correct volume loss and improve skin quality. The hand dorsum is prone to loss of dermal elasticity and ...
Body Skin laxity treatment using hybrid cooperative complexes of hyaluronans: a real-world data evaluation of patient-reported satisfaction
Background: The Profhilo® Body Kit is indicated for the treatment of skin laxity of the body and consists of the Profhilo® Body hyaluronic acid (HA) injectable, the HA-containing Profhilo® Figura Body Patch and the Profhilo® ...
A word of caution in the functional monitoring of patients after rectal cancer surgery: a multicentre observational study
Background: Patients with rectal cancer often experience adverse effects on urinary, sexual, and digestive functions. Despite recognised impacts and available treatments, they are not fully integrated into follow-up ...
Endoscopic Vidian neurectomy for treating postcoital unilateral hydrorhinorrhea: A case report and literature review
Introduction and importance: Hydrorhinorrhea in response to sexual intercourse and orgasm (honeymoon rhinitis) is an underreported clinical presentation producing physical and behavior discomfort. Vidian neurectomy has ...
Unlocking the mind-gut connection: Impact of human microbiome on cognition
This perspective explores the current understanding of the gut microbiota's impact on cognitive function in apparently healthy humans and in individuals with metabolic disease. We discuss how alterations in gut microbiota ...
New synthetic inhibitors of fatty acid synthase with anitcancer activity
Fatty acid synthase (FASN) is a lipogenic enzyme that is highly expressed in different human cancers. Here we report the development of a new series of polyphenolic compounds 5-30 that have been evaluated for their cytotoxic ...
Fatty acid synthase expression is strongly related to menopause in early-stage breast cancer patients
Objective Overexpression of fatty acid synthase (FASN), the enzyme involved in the de novo synthesis of fatty acids, has been reported in several human carcinomas, including breast cancer, and has been related to poor ...
Revitalizing Effect on the Scalp After Injection with a Mechanically Stabilized Hyaluronic Acid Complex in Subjects with Androgenetic Alopecia
Treatments for androgenetic alopecia (AGA) include different drugs, but a treatment based on stabilized hyaluronic acid has not been tested. The aim of this study is to clinically evaluate the effect of six sessions of ...
Are there differences by sex in lung cancer characteristics at diagnosis? -a nationwide study
Background: Lung cancer causes approximately 25% of all cancer deaths. Despite its relevance, few studies have analyzed differences by sex at the time of diagnosis in terms of symptoms, stage, age or smoking status. We aim ...
Challenges and Novel Opportunities of Radiation Therapy for Brain Metastases in Non-Small Cell Lung Cancer
Approximately 20% patients with non-small cell lung cancer (NSCLC) present with CNS spread at the time of diagnosis and 25-50% are found to have brain metastases (BMs) during the course of the disease. The improvement in ...
