Articles publicats Departament de Ciències Mèdiques

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Universitat de Girona Facultat de Lletres

La Universitat de Girona és una institució pública que cerca l’excel·lència en la docència i en la recerca, i que participa en el progrés i el desenvolupament de la societat, mitjançant la creació, transmissió, difusió i crítica de la ciència, la tècnica, les humanitats, les ciències socials i les arts.La Universitat de Girona està arrelada al país i a la cultura catalana i és un dels principals motors econòmics i culturals del seu entorn. Al mateix temps, expressa la vocació d’universalitat i d’obertura a totes les tradicions, avenços i cultures.La Universitat té la seva seu a la ciutat de Girona i s’integra en el sistema d’universitats públiques catalanes.


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Llista ítems afegits recenment

Hyaluronic acid profhilo® alleviates skin inflammation and spinal neuroimmune alterations in a mouse model of atopic dermatitis 

Siquier Dameto, Gabriel Bernat; Jimeno Beltrán, Javier; Bellia, Gilberto; Gori, Andrea; Boadas i Vaello, Pere; Verdú Navarro, Enrique (Publication date: 2026-02-19)

Background and Objectives: Hyaluronic acid (HA) is extensively used in dermo-aesthetic medicine for its hydrating and tissue-repairing properties. Beyond cosmetic use, HA has shown therapeutic effects in inflammatory ...

Unexpected complexity in the molecular diagnosis of spastic paraplegia 11 

Mademont Soler, Irene; Esteba Castillo, Susanna; Jiménez-Xifra, Aida; Alemany, Berta; Ribas Vidal, Núria; Cutillas, Maria; Coll Vidal, Mònica; Pinsach Abuin, Mel·lina; Pagans i Lista, Sara; Alcalde Masegu, Mireia; Viñas Jornet, Marina; Montero-Vale, Mercedes; Castro-Miró, Marta de; Rodríguez, Jairo; Armengol, Lluís; Queralt, Xavier; Obón, María (Publication date: 2024-06)

Background: Spastic paraplegia 11 (SPG11) is the most prevalent form of autosomal recessive hereditary spastic paraplegia, resulting from biallelic pathogenic variants in the SPG11 gene (MIM *610844). Methods: The proband ...

Targeted phasing of 2–200 kilobase DNA fragments with a short-read sequencer and a single-tube linked-read library method 

Mikhaylova, Veronika; Rzepka, Madison; Kawamura, Tetsuya; Xia, Yu; Chang, Peter L.; Zhou, Shiguo; Paasch, Amber; Pham, Long; Modi, Naisarg; Yao, Likun; Pérez Agustín, Adrian; Pagans i Lista, Sara; Boles, T. Christian; Lei, Ming; Wang, Yong; Garcia-Bassets, Ivan; Chen, Zhoutao (Publication date: 2024-04-05)

In the human genome, heterozygous sites refer to genomic positions with a different allele or nucleotide variant on the maternal and paternal chromosomes. Resolving these allelic differences by chromosomal copy, also known ...

Silibinin Overcomes EMT-Driven Lung Cancer Resistance to New-Generation ALK Inhibitors 

Verdura, Sara; Encinar, José Antonio; Teixidor, Eduard; Segura Carretero, Antonio; Micol, Vicente; Cuyàs, Elisabet; Bosch Barrera, Joaquim; Menéndez Menéndez, Javier Abel (Publication date: 2022-12-11)

Epithelial-to-mesenchymal transition (EMT) is a cellular plasticity program that can confer invasiveness, dissemination, and therapy resistance to cancer cells. Although inhibitors of this cellular process are expected to ...

Ultrasound Assessment of Diaphragmatic Function in Children With Cerebral Palsy: A Cross-Sectional Observational Case-Control Study 

Casellas-Vidal, Dolors; Osiniri Kippes, Inés; Font Lladó, Raquel; Camós-Carreras, Maria; Ruiz‐Eizmendi, Aintzane; Serrano Ferrer, Juan; Casellas Vidal, Joaquim; López Bermejo, Abel; Prats Puig, Anna (Publication date: 2026-01)

Background and Aims: Children with cerebral palsy (CP) are vulnerable to respiratory infections and chronic airway inflammation, which leads to diminished respiratory function. This decline is exacerbated by muscle tone ...

Inferences about fossil hominin locomotion through 3D morphometric analysis of wrist ligament insertion sites 

Casado, Aroa; Martínez-Liria, Xavier; San-Millán, Marta; Menés, Laura; Ciurana, Neus; García-Cuesta, Marcel; Rodríguez Cabeza, Patrícia; Pastor, Francisco; Cabo, Roberto; Potau Ginés, Josep Maria (Publication date: 2025-11-27)

Understanding the evolution of wrist anatomy in fossil hominins is essential for reconstructing their locomotor behavior and manipulative capabilities. Traditionally, most studies have focused on bone morphology, overlooking ...

Prevalence of directional asymmetry within the acetabulum and its implications for age estimation 

Warrier, Varsha; San-Millán, Marta; Kanchan, Tanuj (Publication date: 2025-12-06)

Age estimation is a prerequisite for human identification. Within the skeletal framework, pelvic acetabular variables constitute a promising age marker. Previous investigations with the coxal bone have utilised either ...

REIV-TOXO Project: Results from a Spanish cohort of congenital toxoplasmosis (2015-2022). The beneficial effects of prenatal treatment on clinical outcomes of infected newborns 

Guarch-Ibáñez, Borja; Carreras-Abad, Clara; Frick, Marie Antoinette; Blazquez-Gamero, Daniel; Baquero-Artigao, Fernando; Fuentes, Isabel; Soler Palacín, Pere; Spanish Research Network of Congenital Toxoplasmos (Publication date: 2024-10-22)

Background: Some regions of Spain are withdrawing their pregnancy screening program for congenital toxoplasmosis (CT). The Spanish Research Network of Congenital Toxoplasmosis (REIV-TOXO) was created to describe the current ...

Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation 

Latorre Luque, Jèssica; Díaz-Trelles, Ramon; Comas Vila, Ferran; Gavaldà i Navarro, Aleix; Milbank, Edward; Dragano, Nathalia; Morón-Ros, Samantha; Mukthavaram, Rajesh; Ortega, Francisco; Castells Nobau, Anna; Oliveras-Cañellas, Núria; Ricart, Wifredo; Karmali, Priya P.; Tachikawa, Kiyoshi; Chivukula, Pad; Villarroya i Gombau, Francesc; López, Miguel; Giralt i Oms, Marta; Fernández-Real Lemos, José Manuel; Moreno Navarrete, José María (Publication date: 2022-09-13)

Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically ...

Cardiovascular Risk Age Reflects Arterial Status: Middle-Aged People Showed Equivalent Arterial Stiffness to Older People in the Same Risk Category 

Alves Cabratosa, Lia; Elosua Bayés, Marc; Martí Lluch, Ruth; Blanch, Jordi; Tornabell Noguera, Eric; García Gil, María del Mar; Ponjoan Thäns, Anna; Grau, María; Ribas Aulinas, Francesc; Zacarías-Pons, Lluís; Marrugat, Jaume; Ramos Blanes, Rafel (Publication date: 2024)

The concept of risk age may help overcome an excessive weight of age in cardiovascular risk functions. This study aimed to evaluate the equivalence of risk age with arterial stiffness by comparing people with increased ...

Long COVID: cognitive, balance, and retina manifestations 

Carmona Cervelló, Meritxell; León-Gómez, Brenda Biaani; Dacosta-Aguayo, Rosalia; Lamonja-Vicente, Noemí; Montero-Alía, Pilar; Molist, Gemma; Ayet, Aitana; Chacón, Carla; Costa-Garrido, Anna; López-Lifante, Victor M.; Zamora-Putin, Valeria; Liutsko, Liudmila; García-Sierra, Rosa; Fornés, Antònia; Moreno-Gabriel, Eduardo; Massanella, Marta; Muñoz-Moreno, Jose A.; Rodríguez-Pérez, M. Carmen; Mateu, Lourdes; Prats, Anna; Mataró, Maria; Boigues, Marc; Quirant, Bibiana; Prado, Julia G.; Martínez-Cáceres, Eva; Violán Fors, Concepción; Toran Monserrat, Pere; APC Collaborative Group (Publication date: 2024-07-05)

Background: The neurological symptoms of Long COVID (LC) and the impact of neuropsychological manifestations on people’s daily lives have been extensively described. Although a large body of literature describes symptoms, ...

An expert patient program to improve the empowerment and quality of life of people with multiple sclerosis: protocol for a multicenter pre-post intervention study 

Robles Sánchez, Miguel Ángel; Amil-Bujan, Paloma; Bosch Farré, Cristina; Coll-Martinez, Clàudia; Arévalo Navinés, María Jesús; Anglada, Elisenda; Menéndez, Rebeca; Montalban Gairín, Xavier; Sastre Garriga, Jaume; Ramió i Torrentà, Lluís; Bertran i Noguer, Carme (Publication date: 2023-05-18)

Introduction: Multiple sclerosis (MS) causes a progressive disability, which substantially impacts the quality of life (QoL). Health interventions that meet the needs and demands of people with MS are essential to minimize ...

Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study 

Vilalta Lacarra, Anna; Vilalta Franch, Joan; Serrano Sarbosa, Domènec; Martí Lluch, Ruth; Marrugat, Jaume; Garre Olmo, Josep (Publication date: 2023-08-24)

Objective: This study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional depressive symptoms (C-EDS), and antidepressant treatment on mortality due to cancer and other causes in a ...

Combined Systemic and cutaneous ovalbumin-aluminum sensitization triggers thermal hyperalgesia, spinal gliosis, and nociceptive nerve fibers sprouting in mice 

Siquier-Dameto, Gabriel; Gimeno-Beltrán, Javier; Bellia, Gilberto; Boadas i Vaello, Pere; Verdú Navarro, Enrique (Publication date: 2025-09-11)

Background/Objectives: This study investigates whether systemic ovalbumin-aluminum sensitization followed by cutaneous challenge induces thermal hyperalgesia and spinal cord gliosis in mice. Methods: Adult female ICR-CD1 ...

Population-based analysis of breast cancer incidence and mortality: overall and age-specific temporal trends over 40-year period in Girona, Spain 

Sanvisens, Arantza; Vidal-Vila, Anna; Puigdemont, Montserrat; Viñas, Gemma; Roqué Lloveras, Ariadna; Barco, Sonia del; Perez Bueno, Ferran; Trallero, Jan; Marcos-Gragera, Rafael; Renart i Vicens, Gemma (Publication date: 2025-04-25)

Purpose: Breast cancer (BC) incidence and mortality in women have changed over time. This study aims to analyze population-level incidence and mortality trends over 40 years of observation. Methods: Population-based study ...

More Than Three Decades After Discovery of the Neuroprotective Effect of PACAP, What Is Still Preventing Its Clinical Use? 

Cherait, Asma; Xifró i Collsamata, Xavier; Reglodi, Dora; Vaudry, David (Publication date: 2025-06-21)

Discovered in 1989, pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with strong neuroprotective properties, as shown in various neurodegenerative preclinical models of Parkinson, Alzheimer, or ...

Repeated Administrations of Polyphenolic Extracts Prevent Chronic Reflexive and Non-Reflexive Neuropathic Pain Responses by Modulating Gliosis and CCL2-CCR2/CX3CL1-CX3CR1 Signaling in Spinal Cord-Injured Female Mice 

Bagó Mas, Anna; Korimová, Andrea; Bretová, Karolina; Deulofeu, Meritxell; Verdú Navarro, Enrique; Fiol Santaló, Núria; Dubový, Petr; Boadas i Vaello, Pere (Publication date: 2025-04-02)

Neuropathic pain after spinal cord injury lacks any effective treatments, often leading to chronic pain. This study tested whether the daily administration of fully characterized polyphenolic extracts from grape stalks and ...

Soluble receptors for advanced glycation endproducts are predictors of insulin sensitivity and affected by weight loss 

Moreno Navarrete, José María; Leal Moncada, Yenny Teresa; Rosell Díaz , Marisel; Fernández-Real Lemos, José Manuel (Publication date: 2024-10-19)

Background Mice experiments have underscored the efficacy of pharmacological inhibition of advanced glycation endproducts (AGEs) through the use of soluble receptors for advanced glycation endproducts (sRAGE) in mitigating ...

Longitudinal Analysis of Placental IRS1 DNA Methylation and Childhood Obesity 

Gómez-Vilarrubla, Ariadna; Niubó-Pallàs, Maria; Mas Parés, Berta; Bonmatí Santané, Alexandra; Martínez-Calcerrada, José María; López Ibáñez, Beatriz; Peñas Cruz, Aaron; Zegher, Francis de; Ibáñez, Lourdes; López-Bermejo, Abel; Bassols Casadevall, Judit (Publication date: 2025-03-28)

Accumulating evidence suggests that the predisposition to metabolic diseases is established in utero through epigenomic modifications. However, it remains unclear whether childhood obesity results from preexisting epigenomic ...

Health-Related Quality of Life in Men with Fractures and Fear of Falling in General Population: A Cross-Sectional Study 

Zwart Salmerón, Marta; Azagra Ledesma, Rafael; Díaz Herrera, Miguel Ángel; Pujol Salud, Jesús; Sáez Zafra, Marc; Aguyé Batista, Amada (Publication date: 2025-01-30)

Purpose: This study aims to assess how fractures and fear of falling affect health-related quality of life (HRQoL) in men (≥50 years) across different domains. Methods: Design: Observational study. Setting: Primary care. ...

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