Articles publicats Departament de Ciències Mèdiques: Enviaments recents
Ara mostrant els elements 1-20 de 390
Validation and selection of criteria for evaluating apps for managing depression: a Delphi study
Background Despite a lack of evidence relating to effectiveness and safety, the use of apps in the field of mental health is increasing due to their ease of use and accessibility. The aim of the EvalDepApps project is ...
A federated database for obesity research
This work was funded as part of the Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy (SOPHIA) project (SOPHIA; www.imisophia.eu accessed on 15 August 2023). SOPHIA has received funding from the ...
Association between different diet quality scores and depression risk: the REGICOR population-based cohort study
Background: Our aim was to determine the association between diet quality and depression incidence in the population-based REGICOR cohort study, Catalonia, Spain. Methods: Prospective observational study using participants’ ...
Actionable variants of unknown significance in inherited arrhythmogenic syndromes: a further step forward in genetic diagnosis
Background/Objectives: Inherited arrhythmogenic syndromes comprise a heterogenic group of genetic entities that lead to malignant arrhythmias and sudden cardiac death. Genetic testing has become crucial to understand the ...
Drug grouping learning for improving evidence-based treatment recommendations
Clinical practice guidelines (CPGs) are essential tools that facilitate the translation of the growing body of scientific evidence into clinical practice by providing clinicians with evidence-based recommendations. The ...
Fatal intoxications and inherited cardiac disorders in the young: where to draw the line?
Sudden cardiac death represents a significant public health concern and is one of the leading causes of early mortality worldwide. The escalating use of illicit drugs, approximately 269 million people in 2018, represents ...
Unexpected complexity in the molecular diagnosis of spastic paraplegia 11
Background: Spastic paraplegia 11 (SPG11) is the most prevalent form of autosomal recessive hereditary spastic paraplegia, resulting from biallelic pathogenic variants in the SPG11 gene (MIM *610844). Methods: The proband ...
Targeted phasing of 2–200 kilobase DNA fragments with a short-read sequencer and a single-tube linked-read library method
In the human genome, heterozygous sites refer to genomic positions with a different allele or nucleotide variant on the maternal and paternal chromosomes. Resolving these allelic differences by chromosomal copy, also known ...
Silibinin Overcomes EMT-Driven Lung Cancer Resistance to New-Generation ALK Inhibitors
Epithelial-to-mesenchymal transition (EMT) is a cellular plasticity program that can confer invasiveness, dissemination, and therapy resistance to cancer cells. Although inhibitors of this cellular process are expected to ...
Ultrasound Assessment of Diaphragmatic Function in Children With Cerebral Palsy: A Cross-Sectional Observational Case-Control Study
Background and Aims: Children with cerebral palsy (CP) are vulnerable to respiratory infections and chronic airway inflammation, which leads to diminished respiratory function. This decline is exacerbated by muscle tone ...
Inferences about fossil hominin locomotion through 3D morphometric analysis of wrist ligament insertion sites
Understanding the evolution of wrist anatomy in fossil hominins is essential for reconstructing their locomotor behavior and manipulative capabilities. Traditionally, most studies have focused on bone morphology, overlooking ...
Prevalence of directional asymmetry within the acetabulum and its implications for age estimation
Age estimation is a prerequisite for human identification. Within the skeletal framework, pelvic acetabular variables constitute a promising age marker. Previous investigations with the coxal bone have utilised either ...
REIV-TOXO Project: Results from a Spanish cohort of congenital toxoplasmosis (2015-2022). The beneficial effects of prenatal treatment on clinical outcomes of infected newborns
Background: Some regions of Spain are withdrawing their pregnancy screening program for congenital toxoplasmosis (CT). The Spanish Research Network of Congenital Toxoplasmosis (REIV-TOXO) was created to describe the current ...
Downregulation of hepatic lipopolysaccharide binding protein improves lipogenesis-induced liver lipid accumulation
Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically ...
Cardiovascular Risk Age Reflects Arterial Status: Middle-Aged People Showed Equivalent Arterial Stiffness to Older People in the Same Risk Category
The concept of risk age may help overcome an excessive weight of age in cardiovascular risk functions. This study aimed to evaluate the equivalence of risk age with arterial stiffness by comparing people with increased ...
Long COVID: cognitive, balance, and retina manifestations
Background: The neurological symptoms of Long COVID (LC) and the impact of neuropsychological manifestations on people’s daily lives have been extensively described. Although a large body of literature describes symptoms, ...
An expert patient program to improve the empowerment and quality of life of people with multiple sclerosis: protocol for a multicenter pre-post intervention study
Introduction: Multiple sclerosis (MS) causes a progressive disability, which substantially impacts the quality of life (QoL). Health interventions that meet the needs and demands of people with MS are essential to minimize ...
Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
Objective: This study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional depressive symptoms (C-EDS), and antidepressant treatment on mortality due to cancer and other causes in a ...
Combined Systemic and cutaneous ovalbumin-aluminum sensitization triggers thermal hyperalgesia, spinal gliosis, and nociceptive nerve fibers sprouting in mice
Background/Objectives: This study investigates whether systemic ovalbumin-aluminum sensitization followed by cutaneous challenge induces thermal hyperalgesia and spinal cord gliosis in mice. Methods: Adult female ICR-CD1 ...
Population-based analysis of breast cancer incidence and mortality: overall and age-specific temporal trends over 40-year period in Girona, Spain
Purpose: Breast cancer (BC) incidence and mortality in women have changed over time. This study aims to analyze population-level incidence and mortality trends over 40 years of observation. Methods: Population-based study ...
