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Título:	Combating virulence of Gram-negative bacilli by OmpA inhibition
Autor/a:	Vila Farrés, Xavier; Parra-Millán, Raquel; Sánchez Encinales, Viviana; Varese, Monica; Ayerbe Algaba, Rafael; Bayó Puxan, Núria; Guardiola Bagán, Salvador; Pachón Ibáñez, María Eugenia; Kotev, Martin; García Arroyo, Jesús; Teixidó Turà, Meritxell; Vila Estapé, Jordi; Pachón, Jerónimo; Giralt Lledó, Ernest; Smani, Younes
Abstract:	Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of OmpA offers a strategy as monotherapy to address the urgent need for treatments for infections caused by Gram-negative bacilli.
Materia(s):	-Microorganismes patògens -Desenvolupament de medicaments -Pathogenic microorganisms -Drug development
Derechos:	cc by (c) Vila et al., 2017 http://creativecommons.org/licenses/by/3.0/es/
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Macmillan Publishers
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