To access the full text documents, please follow this link: http://hdl.handle.net/2445/122399
Title: | Combating virulence of Gramnegative bacilli by OmpA inhibition |
---|---|
Author: | Vila Farrés, Xavier; Parra Millán, Raquel; Sánchez Encinales, Viviana; Varese, Monica; Ayerbe Algaba, Rafael; Bayó Puxan, Núria; Guardiola, Salvador; Pachón Ibáñez, María Eugenia; Kotev, Martin; García Arroyo, Jesús; Teixidó Turà, Meritxell; Vila Estapé, Jordi; Pachón, Jerónimo; Giralt Lledó, Ernest; Smani, Younes |
Other authors: | Universitat de Barcelona |
Abstract: | Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of OmpA offers a strategy as monotherapy to address the urgent need for treatments for infections caused by Gram-negative bacilli. |
Subject(s): | -Bacteris gramnegatius -Malalties bacterianes -Gram-negative bacteria -Bacterial diseases |
Rights: | cc-by (c) Vila Farres, Xavier et al., 2017
http://creativecommons.org/licenses/by/3.0/es |
Document type: | Article Article - Published version |
Published by: | Nature Publishing Group |
Share: |