Title:
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Stereoselective synthesis of protected peptides containing an anti β‐Hydroxy tyrosine
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Author:
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Fernandez-Valparis, Javier; Romea, Pedro; Urpí Tubella, Fèlix
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Other authors:
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Universitat de Barcelona |
Abstract:
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Protected peptides containing an anti b-hydroxy tyrosine are synthesized in a straightforward and highly efficient manner through the direct and stereoselective addition of N-azidoacetyl-4-isopropyl-1,3-thiazolidine-2-thione to dialkyl acetals catalyzed by a nickel(II) complex, the forging of an amide bond by removal of the chiral auxiliary with an amino ester, and final coupling with a third amino acid. |
Subject(s):
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-Pèptids -Estereoquímica -Quiralitat -Peptides -Stereochemistry -Chirality |
Rights:
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(c) Wiley-VCH, 2019
info:eu-repo/semantics/embargoedAccess |
Document type:
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Article Article - Accepted version |
Published by:
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Wiley-VCH
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