Title:
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Diastereoselective and catalytic α-alkylation of chiral N-acyl thiazolidinethiones with stable carbocationic salts
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Author:
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Kennington, Stuart C. D.; Ferré, Laura; Romo Fernández, Juan Manuel; Romea, Pedro; Urpí Tubella, Fèlix; Font Bardia, Ma. Mercedes
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Other authors:
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Universitat de Barcelona |
Abstract:
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Direct nickel-catalyzed alkylation of chiral N-acyl-4-isopropyl-1,3-thiazolidine-2-thiones using a commercially available nickel(II) complex, (Me3P)2NiCl2, has been developed for tropylium and trityl tetrafluoroborate salts. The reaction provides a single diastereomer of the corresponding adducts in good to high yields, which, in turn, can be easily converted into a wide array of enantiomerically pure compounds that are difficult to obtain by other asymmetric procedures. |
Subject(s):
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-Catàlisi -Níquel -Quiralitat -Catalysis -Nickel -Chirality |
Rights:
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(c) American Chemical Society , 2017
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Document type:
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Article Article - Accepted version |
Published by:
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American Chemical Society
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