Título:
|
Synthesis of Normorphans through an Efficient Intramolecular Carbamoylation of Ketones
|
Autor/a:
|
Diaba, Faïza; Montiel Achong, Juan Andrés; Serban, Georgeta; Bonjoch i Sesé, Josep
|
Otros autores:
|
Universitat de Barcelona |
Abstract:
|
An unexpected C-C bond cleavage was observed in trichloroacetamide-tethered ketones under amine treatment and exploited to develop a new synthesis of normophans from 4-amidocyclohexanones. The reaction involves an unprecedented intramolecular haloform-type reaction of trichloroacetamides promoted by enamines (generated in situ from ketones) as counter-reagents. The methodology was applied to the synthesis of compounds embodying the 6-azabicyclo[3.2.1]octane framework. |
Materia(s):
|
-Cetones -Amines -Síntesi orgànica -Reaccions químiques -Ketones -Amines -Organic synthesis -Chemical reactions |
Derechos:
|
(c) American Chemical Society , 2015
|
Tipo de documento:
|
Artículo Artículo - Versión aceptada |
Editor:
|
American Chemical Society
|
Compartir:
|
|