Understanding the effect of the nature of the nucleobase in the loops on the stability of the i-motif structure

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dc.contributor	Universitat de Barcelona
dc.contributor.author	Benabou Zdaou, Sanae
dc.contributor.author	Garavís, Miguel
dc.contributor.author	Lyonnais, Sébastien
dc.contributor.author	Eritja i Casadellà, Ramon
dc.contributor.author	González, Carlos
dc.contributor.author	Gargallo Gómez, Raimundo
dc.date	2019-02-05T13:25:32Z
dc.date	2019-02-05T13:25:32Z
dc.date	2016-02-09
dc.date	2019-02-05T13:25:32Z
dc.identifier.citation	1463-9076
dc.identifier.citation	656926
dc.identifier.uri	http://hdl.handle.net/2445/127915
dc.format	9 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Royal Society of Chemistry
dc.relation	Versió postprint del document publicat a: https://doi.org/10.1039/C5CP07428B
dc.relation	Physical Chemistry Chemical Physics, 2016, vol. 18, num. 11, p. 7997-8004
dc.relation	https://doi.org/10.1039/C5CP07428B
dc.rights	(c) Benabou Zdaou, Sanae et al., 2016
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	ADN
dc.subject	Espectroscòpia de ressonància magnètica nuclear
dc.subject	Cromatografia de permeació per gel
dc.subject	Electroforesi
dc.subject	DNA
dc.subject	Nuclear magnetic resonance spectroscopy
dc.subject	Gel permeation chromatography
dc.subject	Electrophoresis
dc.title	Understanding the effect of the nature of the nucleobase in the loops on the stability of the i-motif structure
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	The nature and length of loops connecting cytosine tracts in i-motif structures may affect their stability. In this work, the influence of the nature of the nucleobases located in two of the loops of an intramolecular i-motif is studied using spectroscopy, separation techniques, and multivariate data analysis. Insertion of bases other than thymine induces an additional acid-base equilibrium with pKa~4.5. The presence of two guanine bases in the loops, placed opposite to each other, decreases the thermal stability of the structure. In contrast, thymine and cytosine bases in these positions stabilize the structure

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