Bike peptides: a ride through the membrane

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RECERCAT Home > Universitat de Barcelona > Institut de Recerca Biomèdica (IRB Barcelona) > Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/110580

dc.contributor.author	García Pindado, Júlia
dc.contributor.author	Royo, Soledad
dc.contributor.author	Teixidó Turà, Meritxell
dc.contributor.author	Giralt Lledó, Ernest
dc.date	2017-05-08T12:35:56Z
dc.date	2017-05-08T12:35:56Z
dc.date	2017-03-16
dc.date	2017-05-08T12:25:05Z
dc.date	info:eu-repo/date/embargoEnd/2018-03-16
dc.identifier.citation	1075-2617
dc.identifier.uri	http://hdl.handle.net/2445/110580
dc.format	9 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	John Wiley & Sons
dc.relation	Versió postprint del document publicat a: http://dx.doi.org/10.1002/psc.2993
dc.relation	Journal of Peptide Science, 2017, vol. 23, num. 4, p. 294-302
dc.relation	http://dx.doi.org/10.1002/psc.2993
dc.rights	(c) European Peptide Society and John Wiley & Sons, 2017
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	Síntesi de pèptids
dc.subject	Productes naturals
dc.subject	Síntesi orgànica
dc.subject	Peptide synthesis
dc.subject	Natural products
dc.subject	Organic synthesis
dc.title	Bike peptides: a ride through the membrane
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/acceptedVersion
dc.description.abstract	Several natural peptides have a biaryl or biaryl ether motif in their biologically active structures. A model bicyclic pentapeptide containing a biaryl bridge has been synthesized by solid-phase peptide synthesis combining on-resin Suzuki and Miyaura cross-coupling reactions. Its biological properties in terms of permeability, stability and cytotoxicity have been studied, demon-strating the positive contribution of the biaryl bridge, excellent membrane penetration and serum stability

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