Title:
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Bike peptides: a ride through the membrane
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Author:
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García Pindado, Júlia; Royo, Soledad; Teixidó Turà, Meritxell; Giralt Lledó, Ernest
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Abstract:
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Several natural peptides have a biaryl or biaryl ether motif in their biologically active structures. A model bicyclic pentapeptide
containing a biaryl bridge has been synthesized by solid-phase peptide synthesis combining on-resin Suzuki and Miyaura
cross-coupling reactions. Its biological properties in terms of permeability, stability and cytotoxicity have been studied, demon-strating the positive contribution of the biaryl bridge, excellent membrane penetration and serum stability |
Subject(s):
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-Síntesi de pèptids -Productes naturals -Síntesi orgànica -Peptide synthesis -Natural products -Organic synthesis |
Rights:
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(c) European Peptide Society and John Wiley & Sons, 2017
info:eu-repo/semantics/embargoedAccess |
Document type:
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Article Article - Accepted version |
Published by:
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John Wiley & Sons
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