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BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

To access the full text documents, please follow this link: http://hdl.handle.net/20.500.14342/5186

Author

Lucana, Maria C.

Lucchi, Roberta

Gosselet, Fabien

Díaz-Perlas, Cristina

Oller-Salvia, Benjamí

Other authors

Universitat Ramon Llull. IQS

Publication date

2023-12-11



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Abstract

Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood–brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood–brain barrier.

Document Type

Article

Document version

Published version

Language

English

CDU Subject

Subjects and keywords

Protein therapeutics; brain

Pages

5 p.

Publisher

Royal Society of Chemistry

Published in

RSC Chemical Biology. 2024;5(1):7-11

Grant Agreement Number

info:eu-repo/grantAgreement/MCIN-AEI/FPU/19/03216

info:eu-repo/grantAgreement/EC/MSCA-PF/101063066

info:eu-repo/grantAgreement/la Caixa/JuniorLeaders/11840002

info:eu-repo/grantAgreement/la Caixa/INPhINIT/100010434

info:eu-repo/grantAgreement/EC/MSCA /847648

info:eu-repo/grantAgreement/MCIN-AEI/PN I+D/PID2020-117486RA-I00

info:eu-repo/grantAgreement/AECC/IDEAS/IDEAS211057OLLE

info:eu-repo/grantAgreement/SUR del DEC/SGR/SGR-2021-00537

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Attribution 4.0 International

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IQS [794]