Sistema de Salut de Catalunya
Institut Català de la Salut
[Coccia E, Solé M, Comella JX] Grup de Recerca en Senyalització Cel·lular i Apoptosi, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Madrid, Spain. Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
2023-01-09T12:27:26Z
2023-01-09T12:27:26Z
2022-01-10
Alzheimer's disease; Axon remodeling; Synaptic plasticity
Malaltia d'Alzheimer; Remodelació axònica; Plasticitat sinàptica
Enfermedad de Alzheimer; Remodelación axónica; Plasticidad sináptica
Apoptosis is crucial for the correct development of the nervous system. In adulthood, the same protein machinery involved in programmed cell death can control neuronal adaptiveness through modulation of synaptic pruning and synaptic plasticity processes. Caspases are the main executioners in these molecular pathways, and their strict regulation is essential to perform neuronal remodeling preserving cell survival. FAIM-L and SIVA-1 are regulators of caspase activation. In this review we will focus on FAIM-L and SIVA-1 as two functional antagonists that modulate non-apoptotic caspase activity in neurons. Their participation in long-term depression and neurite pruning will be described in base of the latest studies performed. In addition, the association of FAIM-L non-apoptotic functions with the neurodegeneration process will be reviewed.
Article
Published version
English
Sistema nerviós - Fisiologia patològica; Apoptosi; PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis; ANATOMY::Nervous System; Other subheadings::Other subheadings::Other subheadings::/pathology; FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis; ANATOMÍA::sistema nervioso; Otros calificadores::Otros calificadores::Otros calificadores::/patología
Frontiers Media
Frontiers in Cell and Developmental Biology;9
https://doi.org/10.3389/fcell.2021.826037
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
