dc.contributor
Institut Català de la Salut
dc.contributor
[Coccia E, Solé M, Comella JX] Grup de Recerca en Senyalització Cel·lular i Apoptosi, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII, Madrid, Spain. Departament de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Coccia, Elena
dc.contributor.author
Sole Piñol, Montse
dc.contributor.author
Comella, Joan X
dc.date.accessioned
2025-10-25T05:37:48Z
dc.date.available
2025-10-25T05:37:48Z
dc.date.issued
2023-01-09T12:27:26Z
dc.date.issued
2023-01-09T12:27:26Z
dc.date.issued
2022-01-10
dc.identifier
Coccia E, Solé M, Comella JX. FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function. Front Cell Dev Biol. 2022 Jan 10;9:826037.
dc.identifier
https://hdl.handle.net/11351/8756
dc.identifier
10.3389/fcell.2021.826037
dc.identifier
000757361700001
dc.identifier.uri
http://hdl.handle.net/11351/8756
dc.description.abstract
Alzheimer's disease; Axon remodeling; Synaptic plasticity
dc.description.abstract
Malaltia d'Alzheimer; Remodelació axònica; Plasticitat sinàptica
dc.description.abstract
Enfermedad de Alzheimer; Remodelación axónica; Plasticidad sináptica
dc.description.abstract
Apoptosis is crucial for the correct development of the nervous system. In adulthood, the same protein machinery involved in programmed cell death can control neuronal adaptiveness through modulation of synaptic pruning and synaptic plasticity processes. Caspases are the main executioners in these molecular pathways, and their strict regulation is essential to perform neuronal remodeling preserving cell survival. FAIM-L and SIVA-1 are regulators of caspase activation. In this review we will focus on FAIM-L and SIVA-1 as two functional antagonists that modulate non-apoptotic caspase activity in neurons. Their participation in long-term depression and neurite pruning will be described in base of the latest studies performed. In addition, the association of FAIM-L non-apoptotic functions with the neurodegeneration process will be reviewed.
dc.format
application/pdf
dc.publisher
Frontiers Media
dc.relation
Frontiers in Cell and Developmental Biology;9
dc.relation
https://doi.org/10.3389/fcell.2021.826037
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Sistema nerviós - Fisiologia patològica
dc.subject
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
dc.subject
ANATOMY::Nervous System
dc.subject
Other subheadings::Other subheadings::Other subheadings::/pathology
dc.subject
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
dc.subject
ANATOMÍA::sistema nervioso
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/patología
dc.title
FAIM-L - SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
