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dc.contributor.author | Mariño-Sánchez, Franklin Santiago |
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dc.contributor.author | Valls Mateus, Meritxell |
dc.contributor.author | Fragola, C. |
dc.contributor.author | Santos, G. de los |
dc.contributor.author | Aguirre, A. |
dc.contributor.author | Alonso, J. |
dc.contributor.author | Valero, J. |
dc.contributor.author | Santamaría, A. |
dc.contributor.author | Rojas Lechuga, M. J. |
dc.contributor.author | Cobeta, I. |
dc.contributor.author | Alobid, Isam |
dc.contributor.author | Mullol i Miret, Joaquim |
dc.date | 2020-05-04T17:20:46Z |
dc.date | 2020-05-04T17:20:46Z |
dc.date | 2019-01-01 |
dc.date | 2020-02-28T10:37:41Z |
dc.identifier | 5882134 |
dc.identifier.uri | http://hdl.handle.net/2445/158592 |
dc.description | Background: Few odour tests have been created for children. Objectives: The aim of the present study was to develop and validate a simple and quick olfactory test, suitable for the evaluation of odour identification and threshold in a Spanish paediatric population, the paediatric Barcelona Olfactory Test-6 (pBOT-6).The pBOT-6 consisted in a set of 6 odorants for a forced-choice identification test (IT), and a 6 dilutions phenyl ethyl alcohol geometric series for the threshold test (TT). The pBOT-6 was compared with the U-sniff test (a validated international paediatric smell test) in 131 Spanish healthy volunteers aged 6-17 years. A Bland-Altman plot was used to determine the agreement between two tests. Reliability was analyzed in fifteenvolunteers using the intraclass correlation coefficient (ICC). Normative data was obtained and 8 children diagnosed with subjective smell loss were tested for validation.Bland-Altman analysis demonstrated a minimal bias of -1.71% with upper and lower limit of agreement of -31.1% and 27.6%, respectively. The ICC was 0.83 (95% CI 0.6-0.96) for the IT and 0.73 (95% CI 0.36-0.9) for the TT, showing excellent and good consistency between measurements over time. Mean pBOT-6 scores were significantly higher in healthy volunteers compared with patients with smell loss. Discrimination between normosmia and smell loss was achieved with a sensitivity of 96.9% and a specificity of 100%.The pBOT-6 offers an effectiveand fast method useful in clinical routine to distinguish, with high sensitivity and specificity, between paediatric patients with normosmia and those with smell dysfunction. |
dc.format | 24 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Esmon Publicidad S.A. |
dc.relation | Versió postprint del document publicat a: https://doi.org/10.18176/jiaci.0451 |
dc.relation | Journal of Investigational Allergology and Clinical Immunology, 2019, vol. 30, num. 6 |
dc.relation | https://doi.org/10.18176/jiaci.0451 |
dc.rights | (c) Esmon Publicidad S.A., 2019 |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Infants |
dc.subject | Olfactometria |
dc.subject | Children |
dc.subject | Olfactometry |
dc.title | Paediatric Barcelona Olfactory Test-6 (pBOT-6): Validation of a Combined Odour Identification and Threshold Screening Test in Healthy Spanish Children and Adolescents |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/acceptedVersion |