Lifetime psychotic symptoms, subthreshold depression and cognitive impairment as barriers to functional recovery in patients with bipolar disorder

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RECERCAT Home > Universitat de Barcelona > Psicologia Clínica i Psicobiologia > Divulgació i Premsa (Psicologia Clínica i Psicobiologia) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/156560

dc.contributor.author	Bonnín, Caterina del Mar
dc.contributor.author	Jiménez Martínez, Ester
dc.contributor.author	Solé, Brisa
dc.contributor.author	Torrent, Carla
dc.contributor.author	Radua, Joaquim
dc.contributor.author	Reinares, Maria
dc.contributor.author	Grande i Fullana, Iria
dc.contributor.author	Ruíz, Victoria
dc.contributor.author	Sánchez-Moreno, José
dc.contributor.author	Martínez-Arán, Anabel, 1971-
dc.contributor.author	Vieta i Pascual, Eduard, 1963-
dc.date	2020-04-21T18:09:25Z
dc.date	2020-04-21T18:09:25Z
dc.date	2019-07-18
dc.date	2020-04-21T18:09:25Z
dc.identifier	2077-0383
dc.identifier	http://hdl.handle.net/2445/156560
dc.identifier	690896
dc.identifier.uri	http://hdl.handle.net/2445/156560
dc.description	Background: bipolar disorder (BD) is a chronic disease that often leads to functional impairment. The objective of this study is to elucidate which variables are associated with better functional outcomes in a sample of euthymic patients with BD. (2) Methods: patients were recruited at the Hospital Clinic of Barcelona and they underwent a clinical interview, a functional assessment, and a comprehensive neuropsychological evaluation. After that, patients were divided into two groups according to the Functioning Assessment Short Test total score: functionally remitted vs. functionally impaired. Following this, a multivariate logistic regression was run in order to identify clinical, demographic and cognitive factors associated with functional remission. (3) Results: a total of 420 euthymic patients with BD were assessed for this study, distributed as follows: functionally remitted (n = 221) and functionally impaired (n = 199). Finally, the multivariate logistic regression revealed that only five variables significantly contributed to the model, including: lifetime history of psychotic symptoms (the variable that contributed the most to the model), followed by the Hamilton Depression total score, and cognitive performance (executive functions and verbal memory). (4) Conclusions: treatments to ensure a good functional outcome in BD should specially prevent psychosis, target subthreshold depressive symptoms and enhance cognition, more specifically executive functions and verbal memory.
dc.format	14 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	MDPI
dc.relation	Reproducció del document publicat a: https://doi.org/10.3390/jcm8071046
dc.relation	Journal of Clinical Medicine, 2019, vol. 8, num. 7, p. 1046
dc.relation	https://doi.org/10.3390/jcm8071046
dc.rights	cc-by (c) Bonnín, Caterina del Mar et al., 2019
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Trastorn bipolar
dc.subject	Malalts crònics
dc.subject	Psicologia social
dc.subject	Símptomes
dc.subject	Depressió psíquica
dc.subject	Manic-depressive illness
dc.subject	Chronically ill
dc.subject	Social psychology
dc.subject	Symptoms
dc.subject	Mental depression
dc.title	Lifetime psychotic symptoms, subthreshold depression and cognitive impairment as barriers to functional recovery in patients with bipolar disorder
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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