To access the full text documents, please follow this link: http://hdl.handle.net/2445/156048
| dc.contributor.author | Boloc, Daniel |
|---|---|
| dc.contributor.author | Gortat, Anna |
| dc.contributor.author | Cheng-Zhang, Jia Qi |
| dc.contributor.author | García-Cerro, Susana |
| dc.contributor.author | Rodríguez Ferret, Natalia |
| dc.contributor.author | Parellada, Mara |
| dc.contributor.author | Saiz Ruiz, Jerónimo |
| dc.contributor.author | Cuesta, Manuel J. |
| dc.contributor.author | Gassó Astorga, Patricia |
| dc.contributor.author | Lafuente, Amàlia, 1952- |
| dc.contributor.author | Bernardo Arroyo, Miquel |
| dc.contributor.author | Mas Herrero, Sergi |
| dc.date | 2020-04-20T15:24:16Z |
| dc.date | 2020-04-20T15:24:16Z |
| dc.date | 2018-12-13 |
| dc.date | 2020-04-20T15:24:16Z |
| dc.identifier | 2158-3188 |
| dc.identifier | 683468 |
| dc.identifier.uri | http://hdl.handle.net/2445/156048 |
| dc.description | In previous work we developed a pharmacogenetic predictor of antipsychotic (AP) induced extrapyramidal symptoms (EPS) based on four genes involved in mTOR regulation. The main objective is to improve this predictor by increasing its biological plausibility and replication. We re-sequence the four genes using next-generation sequencing. We predict functionality 'in silico' of all identified SNPs and test it using gene reporter assays. Using functional SNPs, we develop a new predictor utilizing machine learning algorithms (Discovery Cohort, N = 131) and replicate it in two independent cohorts (Replication Cohort 1, N = 113; Replication Cohort 2, N = 113). After prioritization, four SNPs were used to develop the pharmacogenetic predictor of AP-induced EPS. The model constructed using the Naive Bayes algorithm achieved a 66% of accuracy in the Discovery Cohort, and similar performances in the replication cohorts. The result is an improved pharmacogenetic predictor of AP-induced EPS, which is more robust and generalizable than the original. |
| dc.format | 10 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Nature Publishing Group |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1038/s41398-018-0330-4 |
| dc.relation | Translational Psychiatry, 2018, vol. 8, num. 1, p. 276 |
| dc.relation | https://doi.org/10.1038/s41398-018-0330-4 |
| dc.rights | cc-by-nc-nd (c) Boloc, Daniel et al., 2018 |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Farmacogenètica |
| dc.subject | Antipsicòtics |
| dc.subject | Pharmacogenetics |
| dc.subject | Antipsychotic drugs |
| dc.title | Improving pharmacogenetic prediction of extrapyramidal symptoms induced by antipshycotics |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
Related documents
Other documents of the same author
Bioque Alcázar, Miquel; Llerena, Adrián; Cabrera, Bibiana; Mezquida, Gisela; Lobo, Antonio; González-Pinto, Ana; Díaz-Caneja, Covadonga M.; Corripio, Iluminada; Aguilar, Eduardo J.; Bulbena Vilarrasa, Antonio; Castro Fornieles, Josefina; Vieta i Pascual, Eduard, 1963-; Lafuente, Amàlia, 1952-; Mas Herrero, Sergi; Parellada, Mara; Sáiz Ruiz, Jerónimo; Cuesta, Manuel J.; Bernardo Arroyo, Miquel; PEPs GROUP; Contreras, Fernando; Gassó Astorga, Patricia
Bioque Alcázar, Miquel; Llerena, Adrián; Cabrera, Bibiana; Mezquida, Gisela; Lobo, Antonio; González-Pinto, Ana; Díaz-Caneja, Covadonga M.; Corripio, Iluminada; Aguilar, Eduardo J.; Bulbena Vilarrasa, Antonio; Castro Fornieles, Josefina; Vieta i Pascual, Eduard, 1963-; Lafuente, Amàlia, 1952-; Mas Herrero, Sergi; Parellada, Mara; Sáiz Ruiz, Jerónimo; Cuesta, Manuel J.; Bernardo Arroyo, Miquel; PEPs GROUP; Contreras, Fernando; Gassó Astorga, Patricia
Rodríguez Ferret, Natalia; Morer Liñan, María Astrid; González Navarro, E. Azucena; Serra Pagès, Carles; Boloc, Daniel; Torres, Teresa; García Cerro, Susana; Mas Herrero, Sergi; Gassó Astorga, Patricia; Lázaro García, Luisa
Rodríguez Ferret, Natalia; Morer Liñan, María Astrid; González Navarro, E. Azucena; Serra Pagès, Carles; Boloc, Daniel; Torres, Teresa; García Cerro, Susana; Mas Herrero, Sergi; Gassó Astorga, Patricia; Lázaro García, Luisa
García Bueno, Borja; Gassó Astorga, Patricia; MacDowell, Karina S.; Callado, Luis F.; Mas Herrero, Sergi; Bernardo Arroyo, Miquel; Lafuente, Amàlia, 1952-; Meana, J.Javier; Leza, Juan C.