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dc.contributor.author | Matas, Jessica |
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dc.contributor.author | Llorenç, Victor |
dc.contributor.author | Fonollosa, Alex |
dc.contributor.author | Esquinas López, Cristina |
dc.contributor.author | Díaz Valle, David |
dc.contributor.author | Berasategui, Barbara |
dc.contributor.author | Mesquida, Marina |
dc.contributor.author | Artaraz, Joseba |
dc.contributor.author | Ríos, José |
dc.contributor.author | Adán Civera, Alfredo |
dc.date | 2020-02-03T12:34:04Z |
dc.date | 2020-02-03T12:34:04Z |
dc.date | 2019-01-24 |
dc.date | 2020-02-03T12:34:04Z |
dc.identifier | 1932-6203 |
dc.identifier | http://hdl.handle.net/2445/149227 |
dc.identifier | 687866 |
dc.identifier.uri | http://hdl.handle.net/2445/149227 |
dc.description | Aims: We aimed to investigate predictive factors for visual and anatomic outcomes in patients with macular edema secondary to non-infectious uveitis. Material and methods: We conducted a multicenter, prospective, observational, 12-month follow-up study. Participants included in the study were adults with non-infectious uveitic macular edema (UME), defined as central subfoveal thickness (CST) of > 300 mu m as measured by spectral domain optical coherence tomography (SD-OCT) and fluid in the macula. Demographic, clinical and tomographic data was recorded at baseline, 1, 3, 6 and 12 months. Foveal-centered SD-OCT exploration was set as the gold-standard determination of UME using a standard Macular Cube 512x128 A-scan, within a 6 x 6 mm(2) area, and the Enhanced High Definition Single-Line Raster. To assess favorable prognosis, the main outcomes analyzed were the best-corrected visual acuity (BCVA) and the CST. Favorable prognosis was defined as sustained improvement of BCVA (2 lines of gain of the Snellen scale) and CST (decrease of 20% of the initial value or < 300 mu m) within a 12 month period. Results: Fifty-six eyes were analyzed. The number of eyes with sustained improvement in the CST was 48 (86.2%), against 23 (41.1%) eyes with sustained improvement in BCVA. Favorable prognosis, as defined above, was observed in 18 (32.1%) eyes. UME prognosis was negatively correlated with baseline foveal thickening, alteration in the vitreo-macular interface and cystoid macular edema. In contrast, bilaterally, systemic disease and the presence of anterior chamber cells were predictive of favorable prognosis. Conclusion: Available treatment modalities in UME may avoid chronic UME and improve anatomic outcome. However, the proportion of functional amelioration observed during 12 months of follow-up is lower. Thicker CST, alteration in the vitreo-macular interface and cystoid macular edema may denote less favorable prognosis. Conversely, bilaterally, systemic disease and anterior chamber cells may be associated with favorable prognosis in UME. |
dc.format | 11 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Public Library of Science (PLoS) |
dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0210799 |
dc.relation | PLoS One, 2019, vol. 14, num. 1, p. e0210799 |
dc.relation | https://doi.org/10.1371/journal.pone.0210799 |
dc.rights | cc-by (c) Matas, Jessica et al., 2019 |
dc.rights | http://creativecommons.org/licenses/by/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Uveïtis |
dc.subject | Edema |
dc.subject | Uveitis |
dc.subject | Edema |
dc.title | Predictors for functional and anatomic outcomes in macular edema secondary to non-infectious uveitis |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |