Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia

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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

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dc.contributor.author	Cillóniz, Catia
dc.contributor.author	Dominedò, Cristina
dc.contributor.author	Ielpo, Antonella
dc.contributor.author	Ferrer Monreal, Miquel
dc.contributor.author	Gabarrús, Albert
dc.contributor.author	Battaglini, Denise
dc.contributor.author	Bermejo Martín, Jesús
dc.contributor.author	Meli, Andrea
dc.contributor.author	Garcia Vidal, Carolina
dc.contributor.author	Liapikou, Adamantia
dc.contributor.author	Singer, Mervyn
dc.contributor.author	Torres Martí, Antoni
dc.date	2019-11-25T12:17:21Z
dc.date	2019-11-25T12:17:21Z
dc.date	2019-07-02
dc.date	2019-10-31T16:51:29Z
dc.identifier	2077-0383
dc.identifier	698278
dc.identifier	5752303
dc.identifier	31269766
dc.identifier.uri	http://hdl.handle.net/2445/145319
dc.description	Little is known about risk and prognostic factors in very old patients developing sepsis secondary to community-acquired pneumonia (CAP). Methods: We conducted a retrospective observational study of data prospectively collected at the Hospital Clinic of Barcelona over a 13-year period. Consecutive patients hospitalized with CAP were included if they were very old (≥80 years) and divided into those with and without sepsis for comparison. Sepsis was diagnosed based on the Sepsis-3 criteria. The main clinical outcome was 30-day mortality. Results: Among the 4219 patients hospitalized with CAP during the study period, 1238 (29%) were very old. The prevalence of sepsis in this age group was 71%. Male sex, chronic renal disease, and diabetes mellitus were independent risk factors for sepsis, while antibiotic therapy before admission was independently associated with a lower risk of sepsis. Thirty-day and intensive care unit (ICU) mortality did not differ between patients with and without sepsis. In CAP-sepsis group, chronic renal disease and neurological disease were independent risk factors for 30-day mortality. Conclusion: In very old patients hospitalized with CAP, in-hospital and 1-year mortality rates were increased if they developed sepsis. Antibiotic therapy before hospital admission was associated with a lower risk of sepsis.
dc.format	12 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	MDPI
dc.relation	Reproducció del document publicat a: https://doi.org/10.3390/jcm8070961
dc.relation	Journal of Clinical Medicine, 2019, vol. 8, num. 7
dc.relation	https://doi.org/10.3390/jcm8070961
dc.rights	cc by (c) Cillóniz et al., 2019
dc.rights	http://creativecommons.org/licenses/by/3.0/es/
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Pneumònia adquirida a la comunitat
dc.subject	Septicèmia
dc.subject	Persones grans
dc.subject	Community-acquired pneumonia
dc.subject	Septicemia
dc.subject	Older people
dc.title	Risk and Prognostic Factors in Very Old Patients with Sepsis Secondary to Community-Acquired Pneumonia
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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