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| dc.contributor.author | Salort, José de |
|---|---|
| dc.contributor.author | Cuenca, Marta |
| dc.contributor.author | Terhorst, Cox |
| dc.contributor.author | Engel Rocamora, Pablo |
| dc.contributor.author | Romero Ros, Xavier |
| dc.date | 2019-08-28T07:48:34Z |
| dc.date | 2019-08-28T07:48:34Z |
| dc.date | 2013-07-31 |
| dc.date | 2019-08-28T07:48:34Z |
| dc.identifier | 1664-3224 |
| dc.identifier | 647380 |
| dc.identifier | 23914190 |
| dc.identifier.uri | http://hdl.handle.net/2445/138757 |
| dc.description | The Signaling Lymphocyte Activation Molecule Family (SLAMF) genes, which encode cell-surface receptors that modulate innate and adaptive immune responses, lay within a genomic region of human and mouse chromosome 1 that confers a predisposition for the development of systemic lupus erythematosus (SLE). Herein, we demonstrate that the SLAMF member Ly9 arises as a novel receptor contributing to the reinforcement of tolerance. Specifically, Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-nuclear antibodies (ANA), -dsDNA, and -nucleosome autoantibodies, independently of genetic background [(B6.129) or (BALB/c.129)]. In aged (10- to 12-month-old) Ly9 (-/-) mice key cell subsets implicated in autoimmunity were expanded, e.g., T follicular helper (Tfh) as well as germinal center (GC) B cells. More importantly, in vitro functional experiments showed that Ly9 acts as an inhibitory receptor of IFN-γ producing CD4(+) T cells. Taken together, our findings reveal that the Ly9 receptor triggers cell intrinsic safeguarding mechanisms to prevent a breach of tolerance, emerging as a new non-redundant inhibitory cell-surface receptor capable of disabling autoantibody responses. |
| dc.format | 12 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Frontiers Media |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2013.00225 |
| dc.relation | Frontiers in Immunology, 2013, vol. 4, num. 225 |
| dc.relation | https://doi.org/10.3389/fimmu.2013.00225 |
| dc.rights | cc-by (c) Salort, Jose de et al., 2013 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Lupus eritematós |
| dc.subject | Autoanticossos |
| dc.subject | Antígens |
| dc.subject | Lupus erythematosus |
| dc.subject | Autoantibodies |
| dc.subject | Antigens |
| dc.title | Ly9 (CD229) cell surface receptor is crucial for the development of spontaneous autoantibody production to nuclear antigens |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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