Bone marrow characterization in COPD: a multi-level network analysis

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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

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dc.contributor.author	Toledo Pons, Nuria
dc.contributor.author	Noell, Guillaume
dc.contributor.author	Jahn, Andreas
dc.contributor.author	Iglesias, Amanda
dc.contributor.author	Duran, Maria Antonia
dc.contributor.author	Iglesias, Julio
dc.contributor.author	Rios, Angel
dc.contributor.author	Scrimini, Sergio
dc.contributor.author	Faner, Rosa
dc.contributor.author	Gigirey, Orlando
dc.contributor.author	Agustí García-Navarro, Àlvar
dc.contributor.author	Cosío, Borja G.
dc.date	2019-05-08T10:06:37Z
dc.date	2019-05-08T10:06:37Z
dc.date	2018-06-15
dc.date	2019-05-08T10:06:37Z
dc.identifier	1465-993X
dc.identifier	686819
dc.identifier	29903047
dc.identifier.uri	http://hdl.handle.net/2445/132830
dc.description	BACKGROUND: Bone marrow (BM) produces hematopoietic and progenitor cells that contribute to distant organ inflammation and repair. Chronic obstructive pulmonary disease (COPD) is characterized by defective lung repair. Yet, BM composition has not been previously characterized in COPD patients. METHODS: In this prospective and controlled study, BM was obtained by sternum fine-needle aspiration in 35 COPD patients and 25 healthy controls (10 smokers and 15 never-smokers). BM cell count and immunophenotype were determined by microscopy and flow cytometry, respectively. Circulating inflammatory (C-reactive protein, IL-6, IL-8) and repair markers (HGF, IGF, TGF-β, VEGF) were quantified by ELISA. Results were integrated by multi-level network correlation analysis. RESULTS: We found that: (1) there were no major significant pair wise differences between COPD patients and controls in the BM structural characteristics; (2) multi-level network analysis including patients and controls identifies a relation between immunity, repair and lung function not previously described, that remains in the COPD network but is absent in controls; and (3) this novel network identifies eosinophils as a potential mediator relating immunity and repair, particularly in patients with emphysema. CONCLUSIONS: Overall, these results suggest that BM is activated in COPD with impaired repair capacity in patients with more emphysema and/or higher circulating eosinophils.
dc.format	10 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	BioMed Central
dc.relation	Reproducció del document publicat a: https://doi.org/10.1186/s12931-018-0824-x
dc.relation	Respiratory Research, 2018, vol. 19, num. 1, p. 118-127
dc.relation	https://doi.org/10.1186/s12931-018-0824-x
dc.rights	cc-by (c) Toledo Pons, Nuria et al., 2018
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Malalties pulmonars obstructives cròniques
dc.subject	Medul·la òssia
dc.subject	Assaigs clínics
dc.subject	Chronic obstructive pulmonary diseases
dc.subject	Bone marrow
dc.subject	Clinical trials
dc.title	Bone marrow characterization in COPD: a multi-level network analysis
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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