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Title:	Targeting prohibitins induces apoptosis in acute myeloid leukemia cells
Author:	Pomares, Helena; Palmeri, Claudia Mariela; Iglesias i Serret, Daniel; Moncunill Massaguer, Cristina; Saura-Esteller, José; Núñez-Vázquez, Sonia; Gamundi, Enric; Arnan, Montserrat; Preciado Gallego, Sara; Albericio Palomera, Fernando; Lavilla Grífols, Rodolfo; Pons i Irazazábal, Gabriel; González Barca, Eva; Cosialls Castel, Ana Mª; Gil i Santano, Joan
Notes:	Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins (PHBs). In this study, the pro-apoptotic effect of fluorizoline was assessed in two cell lines and 21 primary samples from patients with debut of acute myeloid leukemia (AML). Fluorizoline induced apoptosis in AML cells at concentrations in the low micromolar range. All primary samples were sensitive to fluorizoline irrespectively of patients' clinical or genetic features. In addition, fluorizoline inhibited the clonogenic capacity and induced differentiation of AML cells. Fluorizoline increased the mRNA and protein levels of the pro-apoptotic BCL-2 family member NOXA both in cell lines and primary samples analyzed. These results suggest that targeting PHBs could be a new therapeutic strategy for AML
Subject(s):	-Càncer -Leucèmia -Farmacologia -RNA -Tumors -Cancer -Leukemia -Pharmacology -RNA -Tumors
Rights:	cc-by (c) Pomares, Helena et al., 2016 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	Impact Journals
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