Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer

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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

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dc.contributor.author	Navarro Ponz, Alfons
dc.contributor.author	Moisés, Jorge
dc.contributor.author	Santasusagna, Sandra
dc.contributor.author	Marrades Sicart, Ramon Ma.
dc.contributor.author	Viñolas Segarra, Núria
dc.contributor.author	Castellano, Joan Josep
dc.contributor.author	Canals, Jordi
dc.contributor.author	Muñoz García, Carmen
dc.contributor.author	Ramirez, José
dc.contributor.author	Molins López-Rodó, Laureano
dc.contributor.author	Monzó Planella, Mariano
dc.date	2019-03-27T18:41:54Z
dc.date	2019-03-27T18:41:54Z
dc.date	2019-02-28
dc.date	2019-03-27T18:41:54Z
dc.identifier	1471-2466
dc.identifier	689307
dc.identifier	30819158
dc.identifier.uri	http://hdl.handle.net/2445/130991
dc.description	Background HOTTIP, a long non-coding RNA located in the HOXA cluster, plays a role in the patterning of tissues with mesodermal components, including the lung. Overexpression of HOXA genes, including HOTTIP, has been associated with a more aggressive phenotype in several cancers. However, the prognostic impact of HOTTIP has not yet been explored in non-small-cell lung cancer (NSCLC). We have correlated HOTTIP expression with time to relapse (TTR) and overall survival (OS) in early-stage NSCLC patients. Methods Ninety-nine early-stage NSCLC patients who underwent surgical resection in our center from June 2007 to November 2013 were included in the study. Mean age was 66; 77.8% were males; 73.7% had stage I disease; and 55.5% had adenocarcinoma. A validation data set comprised stage I-II patients from The Cancer Genome Atlas (TCGA) Research Network. Results HOTTIP was expressed in all tumor samples and was overexpressed in squamous cell carcinoma (p = 0.007) and in smokers (p = 0.018). Patients with high levels of HOTTIP had shorter TTR (78.3 vs 58 months; p = 0.048) and shorter OS (81.2 vs 61 months; p = 0.023) than those with low levels. In the multivariate analysis, HOTTIP emerged as an independent prognostic marker for TTR (OR: 2.05, 95%CI: 1-4.2; p = 0.05), and for OS (OR: 2.31, 95%CI: 1.04-5.1; p = 0.04). HOTTIP was validated as a prognostic marker for OS in the TCGA adenocarcinoma cohort (p = 0.025). Moreover, we identified a 1203-mRNA and a 61-miRNA signature that correlated with HOTTIP expression. Conclusions The lncRNA HOTTIP can be considered a prognostic biomarker in early-stage NSCLC.
dc.format	9 p.
dc.format	application/pdf
dc.language	eng
dc.publisher	BioMed Central
dc.relation	Reproducció del document publicat a: https://doi.org/10.1186/s12890-019-0816-8
dc.relation	BMC Pulmonary Medicine, 2019, vol. 19, num. 1, p. 55-63
dc.relation	https://doi.org/10.1186/s12890-019-0816-8
dc.rights	cc-by (c) Navarro Ponz, Alfons et al., 2019
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Càncer de pulmó
dc.subject	RNA
dc.subject	Lung cancer
dc.subject	RNA
dc.title	Clinical significance of long non-coding RNA HOTTIP in early-stage non-small-cell lung cancer
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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