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Title:	The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia
Author:	Díaz Beyà, Marina; Brunet, Salut; Nomdedéu Guinot, Josep Francesc; Cordeiro Santanach, Anna; Tormo, Mar; Escoda, Lourdes; Ribera, Josep Maria; Heras, Inmaculada; Gallardo Giralt, David; Bargay, Joan; Queipo de Llano, María Paz; Salamero, Olga; Martí, Josep María; Sampol, Antonia; Pedro, Carme; Hoyos Colell, Montserrat; Pratcorona, Marta; Castellano, Joan Josep; Nomdedeu i Fàbrega, Meritxell; Risueño, Ruth M.; Sierra Gil, Jorge; Monzó Planella, Mariano; Navarro Ponz, Alfons; Esteve Reyner, Jordi; Arnan, Montserrat
Notes:	Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (>= 60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P = 0.0025), shorter leukemia-free survival (P = 0.026) and higher cumulative incidence of relapse (P = 0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P = 0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML.
Subject(s):	-Leucèmia mieloide -Pronòstic mèdic -Malalts de càncer -Micro RNAs -Myeloid leukemia -Prognosis -Cancer patients -MicroRNAs
Rights:	cc-by (c) Diaz Beya, Marina et al., 2015 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	Springer Nature
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