Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/126294
dc.contributor.author | Gaig Ventura, Carles |
---|---|
dc.contributor.author | Vilas Rolán, Dolores |
dc.contributor.author | Infante, Jon |
dc.contributor.author | Sierra, María |
dc.contributor.author | García Gorostiaga, Inés |
dc.contributor.author | Buongiorno, Maria Teresa |
dc.contributor.author | Ezquerra, Mario |
dc.contributor.author | Martí Domènech, Ma. Josep |
dc.contributor.author | Valldeoriola Serra, Francesc |
dc.contributor.author | Aguilar, Miquel |
dc.contributor.author | Calopa, Matilde |
dc.contributor.author | Hernández Vara, Jorge |
dc.contributor.author | Tolosa, Eduardo |
dc.date | 2018-11-21T14:16:53Z |
dc.date | 2018-11-21T14:16:53Z |
dc.date | 2014-10-17 |
dc.date | 2018-07-24T12:37:04Z |
dc.identifier | 25330404 |
dc.identifier.uri | http://hdl.handle.net/2445/126294 |
dc.description | Background: Idiopathic Parkinson's disease (IPD) and LRRK2-associated PD (LRRK2-PD) might be expected to differ clinically since the neuropathological substrate of LRRK2-PD is heterogeneous. The range and severity of extra-nigral nonmotor features associated with LRRK2 mutations is also not well-defined. Objective: To evaluate the prevalence and time of onset of nonmotor symptoms (NMS) in LRRK2-PD patients. Methods: The presence of hyposmia and of neuropsychiatric, dysautonomic and sleep disturbances was assessed in 33 LRRK2-G2019S-PD patients by standardized questionnaires and validated scales. Thirty-three IPD patients, matched for age, gender, duration of parkinsonism and disease severity and 33 healthy subjects were also evaluated. Results: University of Pennsylvania Smell Identification Test (UPSIT) scores in LRRK2-G2019S-PD were higher than those in IPD (23.5 +/- 6.8 vs 18.4 +/- 6.0; p = 0.002), and hyposmia was less frequent in G2019S carriers than in IPD (39.4% vs 75.8%; p = 0.01). UPSIT scores were significantly higher in females than in males in LRRK2-PD patients (26.9 +/- 4.7 vs 19.4 +/- 6.8; p < 0.01). The frequency of sleep and neuropsychiatric disturbances and of dysautonomic symptoms in LRRK2-G2019S-PD was not significantly different from that in IPD. Hyposmia, depression, constipation and excessive daytime sleepiness, were reported to occur before the onset of classical motor symptoms in more than 40% of LRRK2-PD patients in whom these symptoms were present at the time of examination. Conclusion: Neuropsychiatric, dysautonomic and sleep disturbances occur as frequently in patients with LRRK2-G2019S-PD as in IPD but smell loss was less frequent in LRRK2-PD. Like in IPD, disturbances such as hyposmia, depression, constipation and excessive daytime sleepiness may antedate the onset of classical motor symptoms in LRRK2-G2019S-PD. |
dc.format | 9 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Public Library of Science (PLoS) |
dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0108982 |
dc.relation | PLoS One, 2014, vol. 9, num. 10, p. e108982 |
dc.relation | https://doi.org/10.1371/journal.pone.0108982 |
dc.rights | cc by (c) Gaig Ventura et al., 2014 |
dc.rights | http://creativecommons.org/licenses/by/3.0/es/ |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Malaltia de Parkinson |
dc.subject | Trastorns del son |
dc.subject | Parkinson's disease |
dc.subject | Sleep disorders |
dc.title | Nonmotor Symptoms In Lrrk2 G2019s Associated Parkinson's Disease |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |