Intracoronary administration of allogeneic adipose tissue-derived mesenchymal stem cells improves myocardial perfusion but not left ventricle function, in a translational model of acute myocardial infarction

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RECERCAT Home > Universitat de Barcelona > IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer > Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/124319

dc.contributor.author	Bobi, Joaquim
dc.contributor.author	Solanes, Núria
dc.contributor.author	Fernández Jiménez, Rodrigo
dc.contributor.author	Galán Arriola, Carlos
dc.contributor.author	Dantas, Ana Paula
dc.contributor.author	Fernández Friera, Leticia
dc.contributor.author	Gálvez Montón, Carolina
dc.contributor.author	Rigol Monzó, Elisabet
dc.contributor.author	Agüero, Jaume
dc.contributor.author	Ramírez Ruz, J. (José)
dc.contributor.author	Roqué i Moreno, Mercè
dc.contributor.author	Bayés Genís, Antoni
dc.contributor.author	Sánchez González, Javier
dc.contributor.author	García Álvarez, Ana
dc.contributor.author	Sabaté Tenas, Manuel
dc.contributor.author	Roura, Santiago
dc.contributor.author	Ibáñez Cabeza, Borja
dc.contributor.author	Rigol, Montserrat
dc.date	2018-09-05T18:14:44Z
dc.date	2018-09-05T18:14:44Z
dc.date	2017-05-03
dc.date	2018-09-05T18:14:45Z
dc.identifier	2047-9980
dc.identifier	681518
dc.identifier	28468789
dc.identifier.uri	http://hdl.handle.net/2445/124319
dc.description	Background-¿Autologous adipose tissue-derived mesenchymal stem cells (ATMSCs) therapy is a promising strategy to improve post-myocardial infarction outcomes. In a porcine model of acute myocardial infarction, we studied the long-term effects and the mechanisms involved in allogeneic ATMSCs administration on myocardial performance. Methods and Results-¿Thirty-eight pigs underwent 50 minutes of coronary occlusion; the study was completed in 33 pigs. After reperfusion, allogeneic ATMSCs or culture medium (vehicle) were intracoronarily administered. Follow-ups were performed at short (2 days after acute myocardial infarction vehicle-treated, n=10; ATMSCs-treated, n=9) or long term (60 days after acute myocardial infarction vehicle-treated, n=7; ATMSCs-treated, n=7). At short term, infarcted myocardium analysis showed reduced apoptosis in the ATMSCs-treated animals (48.6 6% versus 55.9 5.7% in vehicle; P=0.017); enhancement of the reparative process with up-regulated vascular endothelial growth factor, granulocyte macrophage colony-stimulating factor, and stromal-derived factor-1a gene expression; and increased M2 macrophages (67.2 10% versus 54.7 10.2% in vehicle; P=0.016). In long-term groups, increase in myocardial perfusion at the anterior infarct border was observed both on day-7 and day-60 cardiac magnetic resonance studies in ATMSCs-treated animals, compared to vehicle (87.9 28.7 versus 57.4 17.7 mL/min per gram at 7 days; P=0.034 and 99 22.6 versus 43.3 14.7 22.6 mL/min per gram at 60 days; P=0.0001, respectively). At day 60, higher vascular density was detected at the border zone in the ATMSCs-treated animals (118 18 versus 92.4 24.3 vessels/mm2 in vehicle; P=0.045). Cardiac magnetic resonance-measured left ventricular ejection fraction of left ventricular volumes was not different between groups at any time point. Conclusions-¿In this porcine acute myocardial infarction model, allogeneic ATMSCs-based therapy was associated with increased cardioprotective and reparative mechanisms and with better cardiac magnetic resonance-measured perfusion. No effect on left ventricular volumes or ejection fraction was observed.
dc.format	17 p.
dc.format	application/pdf
dc.language	eng
dc.relation	Reproducció del document publicat a: https://doi.org/10.1161/JAHA.117.005771
dc.relation	Journal Of The American Heart Association, 2017, vol. 6, num. 5, p. e005771
dc.relation	https://doi.org/10.1161/JAHA.117.005771
dc.rights	cc-by-nc (c) Bobi, Joaquim et al., 2017
dc.rights	http://creativecommons.org/licenses/by-nc/3.0/es
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Teixit adipós
dc.subject	Infart de miocardi
dc.subject	Models animals en la investigació
dc.subject	Adipose tissues
dc.subject	Myocardial infarction
dc.subject	Animal models in research
dc.title	Intracoronary administration of allogeneic adipose tissue-derived mesenchymal stem cells improves myocardial perfusion but not left ventricle function, in a translational model of acute myocardial infarction
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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