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dc.contributor.author | Mancera, Pilar |
---|---|
dc.contributor.author | Wappenhans, Blanca |
dc.contributor.author | Cordobilla, Begoña |
dc.contributor.author | Virgili, Noemi |
dc.contributor.author | Pugliese, Marco |
dc.contributor.author | Rueda, Fèlix, 1951- |
dc.contributor.author | Espinosa Parrilla, Juan Francisco |
dc.contributor.author | Domingo, Pere (Domingo Pedrol) |
dc.date | 2018-06-22T11:02:57Z |
dc.date | 2018-06-22T11:02:57Z |
dc.date | 2017-06-30 |
dc.date | 2018-06-22T11:02:57Z |
dc.identifier | 2072-6643 |
dc.identifier | 675426 |
dc.identifier | 28665331 |
dc.identifier.uri | http://hdl.handle.net/2445/123208 |
dc.description | Many neurodegenerative diseases are associated, at least in part, to an inflammatory process in which microglia plays a major role. The effect of the triglyceride form of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (TG-DHA) was assayed in vitro and in vivo to assess the protective and anti-inflammatory activity of this compound. In the in vitro study, BV-2 microglia cells were previously treated with TG-DHA and then activated with Lipopolysaccharide (LPS) and Interferon-gamma (IFN-γ). TG-DHA treatment protected BV-2 microglia cells from oxidative stress toxicity attenuating NO production and suppressing the induction of inflammatory cytokines. When compared with DHA in the ethyl-ester form, a significant difference in the ability to inhibit NO production in favor of TG-DHA was observed. TG-DHA inhibited significantly splenocyte proliferation but isolated CD4+ lymphocyte proliferation was unaffected. In a mice model of autoimmune encephalomyelitis (EAE), 250 mg/kg/day oral TG-DHA treatment was associated with a significant amelioration of the course and severity of the disease as compared to untreated animals. TG-DHA-treated EAE mice showed a better weight profile, which is a symptom related to a better course of encephalomyelitis. TG-DHA may be a promising therapeutic agent in neuroinflammatory processes and merit to be more extensively studied in human neurodegenerative disorders. |
dc.format | 15 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | MDPI |
dc.relation | Reproducció del document publicat a: https://doi.org/10.3390/nu9070681 |
dc.relation | Nutrients, 2017, vol. 9(7), num. 681 |
dc.relation | https://doi.org/10.3390/nu9070681 |
dc.rights | cc-by (c) Mancera, Pilar et al., 2017 |
dc.rights | http://creativecommons.org/licenses/by/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Micròglia |
dc.subject | Estrès oxidatiu |
dc.subject | Microglia |
dc.subject | Oxidative stress |
dc.title | Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |