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Title:	Risk and temporal order of disease diagnosis of comorbidities in patients with COPD: a population health perspective
Author:	Tényi, Ákos; Vela, Emili; Cano Franco, Isaac; Cleries, Montserrat; Monterde Prat, David; Gomez Cabrero, David; Roca Torrent, Josep
Notes:	Introduction: Comorbidities in patients with chronic obstructive pulmonary disease (COPD) generate a major burden on ealthcare. Identification of costeffective strategies aiming at preventing and enhancing management of comorbid conditions in patients with COPD requires deeper knowledge on epidemiological patterns and on shared biological pathways xplaining cooccurrence of diseases. Methods: The study assesses the co-occurrence of several chronic conditions in patients with COPD using two different datasets: Catalan Healthcare Surveillance System (CHSS) (ES, 1.4 million registries) and Medicare (USA, 13 million registries). Temporal order of disease diagnosis was analysed in the CHSS dataset. Results The results demonstrate higher prevalence of most of the diseases, as comorbid conditions, in elderly (>65) patients with COPD compared with non-COPD subjects, an effect observed in both CHSS and Medicare datasets. Analysis of temporal order of disease diagnosis showed that comorbid conditions in elderly patients with COPD tend to appear after the diagnosis of the obstructive disease, rather than before it. Conclusion: The results provide a population health perspective of the comorbidity challenge in patients with COPD, indicating the increased risk of developing comorbid conditions in these patients. The research reinforces the need for novel approaches in the prevention and management of comorbidities in patients with COPD to effectively reduce the overall burden of the disease on these patients.
Subject(s):	-Malalties pulmonars obstructives cròniques -Comorbiditat -Salut pública -Chronic obstructive pulmonary diseases -Comorbidity -Public health
Rights:	cc-by-nc (c) Tényi, Ákos et al., 2018 http://creativecommons.org/licenses/by-nc/3.0/es
Document type:	Article Article - Published version
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