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| dc.contributor.author | Gumus, Hatice Gulcin |
|---|---|
| dc.contributor.author | Illa Armengol, Míriam |
| dc.contributor.author | Pla, Laura |
| dc.contributor.author | Zamora, Monica |
| dc.contributor.author | Crispi Brillas, Fàtima |
| dc.contributor.author | Gratacós Solsona, Eduard |
| dc.date | 2018-04-24T11:42:27Z |
| dc.date | 2018-04-24T11:42:27Z |
| dc.date | 2018-02-21 |
| dc.date | 2018-04-24T11:42:27Z |
| dc.identifier | 1932-6203 |
| dc.identifier | 678932 |
| dc.identifier | 29466434 |
| dc.identifier.uri | http://hdl.handle.net/2445/121819 |
| dc.description | Objective To evaluate the perinatal effects of a prenatal therapy based on intra-amniotic nutritional supplementation in a rabbit model of intrauterine growth restriction (IUGR). Methods IUGR was surgically induced in pregnant rabbits at gestational day 25 by ligating 40-50% of uteroplacental vessels of each gestational sac. At the same time, modified-parenteral nutrition solution (containing glucose, amino acids and electrolytes) was injected into the amniotic sac of nearly half of the IUGR fetuses (IUGR-T group n = 106), whereas sham injections were performed in the rest of fetuses (IUGR group n = 118). A control group without IUGR induction but sham injection was also included (n = 115). Five days after the ligation procedure, a cesarean section was performed to evaluate fetal cardiac function, survival and birth weight. Results Survival was significantly improved in the IUGR fetuses that were treated with intra-amniotic nutritional supplementation as compared to non-treated IUGR animals (survival rate: controls 71% vs. IUGR 44% p = 0.003 and IUGR-T 63% vs. IUGR 44% p = 0.02), whereas, birth weight (controls mean 43g ± SD 9 vs. IUGR 36g ± SD 9 vs. IUGR-T 35g ± SD 8, p = 0.001) and fetal cardiac function were similar among the IUGR groups. Conclusion Intra-amniotic injection of a modified-parenteral nutrient solution appears to be a promising therapy for reducing mortality among IUGR. These results provide an opportunity to develop new intra-amniotic nutritional strategies to reach the fetus by bypassing the placental insufficiency |
| dc.format | 13 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Public Library of Science (PLoS) |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0193240 |
| dc.relation | PLoS One, 2018, vol. 13, num. 2, p. e0193240 |
| dc.relation | https://doi.org/10.1371/journal.pone.0193240 |
| dc.rights | cc-by (c) Gumus, Hatice Gulcin et al., 2018 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Medicina prenatal |
| dc.subject | Nutrició |
| dc.subject | Prenatal medicine |
| dc.subject | Nutrition |
| dc.title | Nutritional intra-amniotic therapy increases survival in a rabbit model of fetal growth restriction |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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