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dc.contributor.author | Mesquida, Marina |
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dc.contributor.author | Molins Monteys, Blanca |
dc.contributor.author | Llorenç, Victor |
dc.contributor.author | Sainz de la Maza, Maite |
dc.contributor.author | Hernandez, Maria Victoria |
dc.contributor.author | Espinosa Garriga, Gerard |
dc.contributor.author | Adán Civera, Alfredo |
dc.date | 2018-02-08T11:21:49Z |
dc.date | 2018-02-08T11:21:49Z |
dc.date | 2014-06-08 |
dc.date | 2018-02-08T11:21:49Z |
dc.identifier | 0962-9351 |
dc.identifier | 663786 |
dc.identifier | 24994946 |
dc.identifier.uri | http://hdl.handle.net/2445/119678 |
dc.description | The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Behcet's disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-gamma (IFN-gamma), interleukin-1 beta (IL-1 beta), IL-12p70, IL-17A, tumor necrosis factor-alpha (TNF-alpha), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-gamma and TNF-alpha were significantly increased in patients with active uveitis associated to BD compared to controls (P < 0.05). IFN-gamma, TNF-alpha, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (P < 0.05). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (P < 0.05). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-gamma, TNF-alpha, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity. |
dc.format | 9 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Hindawi Publishing Corporation |
dc.relation | Reproducció del document publicat a: https://doi.org/10.1155/2014/396204 |
dc.relation | Mediators of Inflammation, 2014, vol. 2014 |
dc.relation | https://doi.org/10.1155/2014/396204 |
dc.rights | cc-by (c) Mesquida, Marina et al., 2014 |
dc.rights | http://creativecommons.org/licenses/by/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Citoquines |
dc.subject | Proteïnes de la sang |
dc.subject | Uveïtis |
dc.subject | Malaltia de Behçet |
dc.subject | Inflamació |
dc.subject | Cytokines |
dc.subject | Blood proteins |
dc.subject | Uveitis |
dc.subject | Behçet's disease |
dc.subject | Inflammation |
dc.title | Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |