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| dc.contributor.author | Martínez Mármol, Ramón |
|---|---|
| dc.contributor.author | Barneda Zahonero, Bruna |
| dc.contributor.author | Soto del Cerro, David |
| dc.contributor.author | Andrés, Rosa Maria |
| dc.contributor.author | Coccia, Elena |
| dc.contributor.author | Gasull Casanova, Xavier |
| dc.contributor.author | Planells-Ferrer, Laura |
| dc.contributor.author | Moubarak, Rana S. |
| dc.contributor.author | Soriano García, Eduardo |
| dc.contributor.author | Comella i Carnicé, Joan Xavier, 1963- |
| dc.date | 2017-10-13T14:03:32Z |
| dc.date | 2017-10-13T14:03:32Z |
| dc.date | 2016-10-21 |
| dc.date | 2017-10-13T14:03:32Z |
| dc.identifier | 2045-2322 |
| dc.identifier | 666959 |
| dc.identifier | 27767058 |
| dc.identifier.uri | http://hdl.handle.net/2445/116597 |
| dc.description | Caspases have recently emerged as key regulators of axonal pruning and degeneration and of long-term depression (LTD), a long-lasting form of synaptic plasticity. However, the mechanism underlying these functions remains unclear. In this context, XIAP has been shown to modulate these processes. The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L modulates synaptic transmission, prevents chemical-LTD induction in hippocampal neurons, and thwarts axon degeneration after nerve growth factor (NGF) withdrawal. Additionally, we demonstrate that the participation of FAIM-L in these two processes is dependent on its capacity to stabilize XIAP protein levels. Our data reveal FAIM-L as a regulator of axonal degeneration and synaptic plasticity. |
| dc.format | 16 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Nature Publishing Group |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1038/srep35775 |
| dc.relation | Scientific Reports, 2016, vol. 6, p. 35775 |
| dc.relation | https://doi.org/10.1038/srep35775 |
| dc.rights | cc-by (c) Martínez-Mármol, Ramón et al., 2016 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Apoptosi |
| dc.subject | Malalties del sistema nerviós |
| dc.subject | Apoptosis |
| dc.subject | Nervous system diseases |
| dc.title | FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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