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| dc.contributor.author | Torres, Berta |
|---|---|
| dc.contributor.author | Guardo, Alberto C. |
| dc.contributor.author | Leal, Lorna |
| dc.contributor.author | León García, Agathe |
| dc.contributor.author | Lucero, Constanza |
| dc.contributor.author | Álvarez Martínez, Míriam |
| dc.contributor.author | Martínez Yoldi, Miguel Julián |
| dc.contributor.author | Vila Estapé, Jordi |
| dc.contributor.author | Martínez Rebollar, María |
| dc.contributor.author | González Cordón, Ana |
| dc.contributor.author | Gatell, José M. |
| dc.contributor.author | Plana Prades, Montserrat |
| dc.contributor.author | García Alcaide, Felipe |
| dc.date | 2017-05-17T09:45:39Z |
| dc.date | 2017-05-17T09:45:39Z |
| dc.date | 2014-09-29 |
| dc.date | 2017-05-17T09:45:39Z |
| dc.identifier | 1758-2652 |
| dc.identifier | 643591 |
| dc.identifier | 25280865 |
| dc.identifier.uri | http://hdl.handle.net/2445/111156 |
| dc.description | Introduction Monotherapy with protease-inhibitors (MPI) may be an alternative to cART for HIV treatment. We assessed the impact of this strategy on immune activation, bacterial translocation and inflammation. Methods We performed a cross-sectional study comparing patients on successful MPI (n=40) with patients on cART (n=20). Activation, senescence, exhaustion and differentiation stage in CD4+ and CD8+ T lymphocyte subsets, markers of monocyte activation, microbial translocation, inflammation, coagulation and low-level viremia were assessed. Results CD4+ or CD8+ T lymphocyte subset parameters were not significantly different between both groups. Conversely, as compared with triple cART, MPI patients showed a higher proportion of activated monocytes (CD14+ CD16−CD163+ cells, p=0.031), soluble markers of monocyte activation (sCD14 p=0.004, sCD163 p=0.002), microbial translocation (lipopolysaccharide (LPS)-binding protein; LBP p=0.07), inflammation (IL-6 p=0.04) and low-level viremia (p=0.035). In a multivariate model, a higher level of CD14+ CD16−CD163+ cells and sCD14, and presence of very low-level viremia were independently associated with MPI. Monocyte activation was independently associated with markers of inflammation (IL-6, p=0.006), microbial translocation (LBP, p=0.01) and low-level viremia (p=0.01). Conclusions Patients on MPI showed a higher level of monocyte activation than patients on standard therapy. Microbial translocation and low-level viremia were associated with the high level of monocyte activation observed in patients on MPI. The long-term clinical consequences of these findings should be assessed. |
| dc.format | 8 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | BioMed Central |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.7448/IAS.17.1.19246 |
| dc.relation | Journal of the International AIDS Society, 2014, vol. 17, num. 1, p. 19246 |
| dc.relation | https://doi.org/10.7448/IAS.17.1.19246 |
| dc.rights | cc-by (c) Torres, Berta et al., 2014 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | VIH (Virus) |
| dc.subject | Antiretrovirals |
| dc.subject | Limfòcits |
| dc.subject | Translocació (Genètica) |
| dc.subject | Inhibidors enzimàtics |
| dc.subject | HIV (Viruses) |
| dc.subject | Antiretroviral agents |
| dc.subject | Lymphocytes |
| dc.subject | Translocation (Genetics) |
| dc.subject | Enzyme inhibitors |
| dc.title | Protease inhibitor monotherapy is associated with a higher level of monocyte activation, bacterial translocation and inflammation |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
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