Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/108858
| dc.contributor.author | Alsina, Laia |
|---|---|
| dc.contributor.author | Basteiro, Maria G. |
| dc.contributor.author | Paz, Hector D.de |
| dc.contributor.author | Iñigo, Melania |
| dc.contributor.author | Fernández de Sevilla Estrach, Mariona |
| dc.contributor.author | Triviño, Miriam |
| dc.contributor.author | Juan, Manel |
| dc.contributor.author | Muñoz-Almagro, Carmen |
| dc.date | 2017-03-23T18:39:13Z |
| dc.date | 2017-03-23T18:39:13Z |
| dc.date | 2015-03-04 |
| dc.date | 2017-03-23T18:39:13Z |
| dc.identifier | 1932-6203 |
| dc.identifier | 669509 |
| dc.identifier | 25738983 |
| dc.identifier.uri | http://hdl.handle.net/2445/108858 |
| dc.description | Purpose Clinical, immunological and microbiological characteristics of recurrent invasive pneumo-coccal disease (IPD) in children were evaluated, differentiating relapse from reinfection, in order to identify specific risk factors for both conditions. Methods All patients<18 years-old with recurrent IPD admitted to a tertiary-care pediatric center from January 2004 to December 2011 were evaluated. An episode of IPD was defined as the presence of clinical findings of infection together with isolation and/or pneumococcal DNA detection by Real-Time PCR in any sterile body fluid. Recurrent IPD was defined as 2 or more episodes in the same individual at least 1 month apart. Among recurrent IPD, we differentiated relapse (same pneumococcal isolate) from reinfection. Results 593 patients were diagnosed with IPD and 10 patients died. Among survivors, 23 episodes of recurrent IPD were identified in 10 patients (1.7%). Meningitis was the most frequent form of recurrent IPD (10 episodes/4 children) followed by recurrent empyema (8 episodes/4 children). Three patients with recurrent empyema caused by the same pneumococcal clone ST306 were considered relapses and showed high bacterial load in their first episode. In contrast, all other episodes of recurrent IPD were considered reinfections. Overall, the rate of relapse of IPD was 0.5% and the rate of reinfection 1.2%. Five out of 7 patients with rein- fection had an underlying risk factor: cerebrospinal fluid leak (n = 3), chemotherapy treatment (n = 1) and a homozygous mutation in MyD88 gene (n = 1). No predisposing risk factors were found in the remainder. Conclusions recurrent IPD in children is a rare condition associated with an identifiable risk factor in case of reinfection in almost 80% of cases. In contrast, recurrent IPD with pleuropneumonia is usually a relapse of infection. |
| dc.format | 13 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Public Library of Science (PLoS) |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0118848 |
| dc.relation | PLoS One, 2015, vol. 10, num. 3, p. e0118848 |
| dc.relation | https://doi.org/10.1371/journal.pone.0118848 |
| dc.rights | cc-by (c) Alsina, Laia et al., 2015 |
| dc.rights | http://creativecommons.org/licenses/by/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Infeccions per pneumococs |
| dc.subject | Pneumococs |
| dc.subject | Pediatria |
| dc.subject | Infants |
| dc.subject | Immunologia |
| dc.subject | Pneumònia |
| dc.subject | Pneumococcal Infections |
| dc.subject | Streptococcus pneumonia |
| dc.subject | Pediatrics |
| dc.subject | Children |
| dc.subject | Immunology |
| dc.subject | Pneumonia |
| dc.title | Recurrent invasive pneumococcal disease in children: Underlying clinical conditions, and immunological and microbiological characteristics. |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/publishedVersion |
Documentos relacionados
Otros documentos del mismo autor/a
Alsina, Laia; Basteiro, Maria G.; Paz, Hector D.de; Iñigo, Melania; Fernández de Sevilla Estrach, Mariona; Triviño, Miriam; Juan, Manel; Muñoz-Almagro, Carmen
Armangué, Thaís; Spatola, Marianna; Vlagea, Alexandru; Mattozzi, Simone; Cárceles-Cordón, Marc; Martinez-Heras, Eloy; Llufriu Duran, Sara; Muchart López, Jordi; Erro, María Elena; Abraira, Laura; Moris, German; Monros-Gimenez, Luis; Corral-Corral, Íñigo; Montejo, Carmen; Toledo, Manuel; Bataller, Luis; Secondi, Gabriela; Ariño Rodríguez, Helena; Martinez-Hernandez, Eugenia; Juan, Manel; Marcos, Ma. Angeles; Alsina, Laia; Saiz Hinajeros, Albert; Rosenfeld, Myrna R.; Graus Ribas, Francesc; Dalmau Obrador, Josep; Spanish Herpes Simplex Encephalitis Study Group
Armangué, Thaís; Spatola, Marianna; Vlagea, Alexandru; Mattozzi, Simone; Cárceles-Cordón, Marc; Martinez-Heras, Eloy; Llufriu Duran, Sara; Muchart López, Jordi; Erro, María Elena; Abraira, Laura; Moris, German; Monros-Gimenez, Luis; Corral-Corral, Íñigo; Montejo, Carmen; Toledo, Manuel; Bataller, Luis; Secondi, Gabriela; Ariño Rodríguez, Helena; Martinez-Hernandez, Eugenia; Juan, Manel; Marcos, Ma. Angeles; Alsina, Laia; Saiz Hinajeros, Albert; Rosenfeld, Myrna R.; Graus Ribas, Francesc; Dalmau Obrador, Josep; Spanish Herpes Simplex Encephalitis Study Group
Armangué, Thaís; Spatola, Marianna; Vlagea, Alexandru; Mattozzi, Simone; Cárceles-Cordón, Marc; Martínez-Heras, Eloy; Llufriu Duran, Sara; Muchart López, Jordi; Erro, María Elena; Abraira, Laura; Moris, German; Monros-Gimenez, Luis; Corral-Corral, Íñigo; Montejo, Carmen; Toledo, Manuel; Bataller, Luis; Secondi, Gabriela; Ariño Rodríguez, Helena; Martínez Hernández, Eugenia; Juan, Manel; Marcos, Ma. Angeles; Alsina, Laia; Saiz Hinajeros, Albert; Rosenfeld, Myrna R.; Graus Ribas, Francesc; Dalmau Obrador, Josep; Spanish Herpes Simplex Encephalitis Study Group
Selva Jové, Laura; Benmessaoud, Rachid; Lanaspa, Miguel; Jroundi, Imane; Moraleda, Cinta; Acácio, Sozinho; Iñigo, Melania; Bastiani, Alien; Monsonis, Manuel; Pallarés Giner, Roman; Bassat Orellana, Quique; Muñoz-Almagro, Carmen