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Title:	Genetic Variants Associated with Colorectal Adenoma Susceptibility
Author:	Abulí, Anna; Castells Garangou, Antoni; Bujanda, Luis; Lozano Salvatella, Juan José; Bessa i Caserras, Xavier; Hernández-Munain, Cristina; Álvarez Urturi, Cristina; Pellisé Urquiza, Maria; Esteban-Jurado, Clara; Hijona, Elizabeth; Burón, Andrea; Macià, Francesc; Grau Cano, J. (Jaume); Guayta, Rafael (Guayta Escolies); Castellví Bel, Sergi; Andreu, Montserrat; Trilla García, Antoni; PROCOLON Research Group
Notes:	Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population.
Subject(s):	-Càncer colorectal -Genètica humana -Estudi de casos -Mutació (Biologia) -Colonoscòpia -Colorectal cancer -Human genetics -Case studies -Mutation (Biology) -Colonoscopy
Rights:	cc-by (c) Abulí, Anna et al., 2016 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	Public Library of Science (PLoS)
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