dc.contributor.author |
Ghosh, Eshan |
dc.contributor.author |
Dwivedi, Hemlata |
dc.contributor.author |
Baidya, Mithu |
dc.contributor.author |
Srivastava, Ashish |
dc.contributor.author |
Kumari, Punita |
dc.contributor.author |
Stepniewski, Tomek |
dc.contributor.author |
Kim, Hee Ryung |
dc.contributor.author |
Lee, Mi-Hye |
dc.contributor.author |
van Gastel, Jana |
dc.contributor.author |
Chaturvedi, Madhu |
dc.contributor.author |
Roy, Debarati |
dc.contributor.author |
Pandey, Shubhi |
dc.contributor.author |
Maharana, Jagannath |
dc.contributor.author |
Guixà González, Ramon |
dc.contributor.author |
Luttrell, Louis M. |
dc.contributor.author |
Chung, Ka Young |
dc.contributor.author |
Dutta, Somnath |
dc.contributor.author |
Selent, Jana |
dc.contributor.author |
Shukla, Arun K. |
dc.date |
2019 |
dc.identifier |
https://ddd.uab.cat/record/224183 |
dc.identifier |
urn:10.1016/j.celrep.2019.08.053 |
dc.identifier |
urn:oai:ddd.uab.cat:224183 |
dc.identifier |
urn:pmid:31553900 |
dc.identifier |
urn:scopus_id:85072193756 |
dc.identifier |
urn:articleid:22111247v28n13p3287 |
dc.identifier |
urn:oai:egreta.uab.cat:publications/f0bc3ccd-6dc7-44f8-a5a0-4ee8fd8eaee5 |
dc.identifier |
urn:pmc-uid:7099875 |
dc.identifier |
urn:pmcid:PMC7099875 |
dc.identifier |
urn:oai:pubmedcentral.nih.gov:7099875 |
dc.format |
application/pdf |
dc.language |
eng |
dc.publisher |
|
dc.relation |
Instituto de Salud Carlos III PI15/0046 |
dc.relation |
Instituto de Salud Carlos III PI18/00094 |
dc.relation |
Cell reports ; Vol. 28 Núm. 13 (24 2019), p. 3287-3299.e6 |
dc.rights |
open access |
dc.rights |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
dc.rights |
https://creativecommons.org/licenses/by/4.0/ |
dc.subject |
GPCRs |
dc.subject |
β-arrestins |
dc.subject |
Cellular signaling |
dc.subject |
Antibody fragments |
dc.subject |
Biosensors |
dc.subject |
Biased agonism |
dc.subject |
Desensitization |
dc.subject |
Negative staining |
dc.subject |
Electron microscopy |
dc.title |
Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms |
dc.type |
Article |
dc.description.abstract |
Ghosh et al. discover structural differences between β-arrestin isoforms (β-arrestin 1 and 2), which are universal regulators of signaling and trafficking of G-protein-coupled receptors (GPCRs). These findings have direct implications for understanding the regulatory and signaling paradigms of GPCRs and designing novel therapeutics targeting this important class of receptors. |