Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms

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Title:	Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms
Author:	Ghosh, Eshan; Dwivedi, Hemlata; Baidya, Mithu; Srivastava, Ashish; Kumari, Punita; Stepniewski, Tomek; Kim, Hee Ryung; Lee, Mi-Hye; van Gastel, Jana; Chaturvedi, Madhu; Roy, Debarati; Pandey, Shubhi; Maharana, Jagannath; Guixà González, Ramon; Luttrell, Louis M.; Chung, Ka Young; Dutta, Somnath; Selent, Jana; Shukla, Arun K.
Abstract:	Ghosh et al. discover structural differences between β-arrestin isoforms (β-arrestin 1 and 2), which are universal regulators of signaling and trafficking of G-protein-coupled receptors (GPCRs). These findings have direct implications for understanding the regulatory and signaling paradigms of GPCRs and designing novel therapeutics targeting this important class of receptors.
Subject(s):	-GPCRs -β-arrestins -Cellular signaling -Antibody fragments -Biosensors -Biased agonism -Desensitization -Negative staining -Electron microscopy
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Document type:	Article
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Uri:	https://ddd.uab.cat/record/224183