Títol:
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HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells
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Autor/a:
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Pino, Maria; Erkizia, Itziar; Benet, Susana; Erikson, Elina; Fernandez Figueras, Maria Teresa; Guerrero, Dolores; Dalmau, Judith; Ouchi, Dan; Rausell, Antonio; Ciuffi, Angela; Keppler, Oliver T.; Telenti, Amalio; Kräusslich, Hans-Georg; Martínez Picado, Francisco Javier; Izquierdo Useros, Nuria; Universitat Autònoma de Barcelona
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Abstract:
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Altres ajuts: Red Temática Cooperativa de Investigación en SIDA (RD06/0006) i Mathilde Krim Fellowship in basic biomedical research 108676 |
Abstract:
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Myeloid cells are key players in the recognition and response of the host against invading viruses. Paradoxically, upon HIV-1 infection, myeloid cells might also promote viral pathogenesis through trans-infection, a mechanism that promotes HIV-1 transmission to target cells via viral capture and storage. The receptor Siglec-1 (CD169) potently enhances HIV-1 trans-infection and is regulated by immune activating signals present throughout the course of HIV-1 infection, such as interferon α (IFNα). Here we show that IFNα-activated dendritic cells, monocytes and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides. Monocytes from untreated HIV-1-infected individuals trans-infect HIV-1 via Siglec-1, but this capacity diminishes after effective antiretroviral treatment. Furthermore, Siglec-1 is expressed on myeloid cells residing in lymphoid tissues, where it can mediate viral trans-infection. Siglec-1 on myeloid cells could fuel novel CD4(+) T-cell infections and contribute to HIV-1 dissemination in vivo. |
Matèries:
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-Dendritic cells -HIV-1 -Trans-infection -Siglec-1 |
Drets:
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open access
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Article |
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Uri:
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https://ddd.uab.cat/record/163263
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