Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer

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dc.contributor	Universitat de Barcelona
dc.contributor.author	Navarro Brugal, Gemma
dc.contributor.author	Carriba, Paulina
dc.contributor.author	Gandía, Jorge
dc.contributor.author	Ciruela Alférez, Francisco
dc.contributor.author	Casadó, Vicent
dc.contributor.author	Cortés Tejedor, Antonio
dc.contributor.author	Mallol Montero, Josefa
dc.contributor.author	Canela Campos, Enric I.
dc.contributor.author	Lluís i Biset, Carme
dc.contributor.author	Franco Fernández, Rafael
dc.date	2018-05-17T15:13:56Z
dc.date	2018-05-17T15:13:56Z
dc.date	2008-10-11
dc.date	2018-05-17T15:13:56Z
dc.identifier.citation	1537-744X
dc.identifier.citation	564241
dc.identifier.uri	http://hdl.handle.net/2445/122431
dc.format	11 p.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Hindawi
dc.relation	Reproducció del document publicat a: https://doi.org/10.1100/tsw.2008.136
dc.relation	Scientific World Journal, 2008, vol. 8, p. 1088-1097
dc.relation	https://doi.org/10.1100/tsw.2008.136
dc.rights	cc-by (c) Navarro Brugal, Gemma et al., 2008
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by/3.0/es
dc.subject	Adenosina
dc.subject	Proteïnes
dc.subject	Receptors cel·lulars
dc.subject	Adenosine
dc.subject	Proteins
dc.subject	Cell receptors
dc.title	Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Functional interactions in signaling occur between dopamine D2 (D2R) and cannabinoid CB1 (CB1R) receptors, between CB1R and adenosine A2A (A2AR) receptors, and between D2R and A2AR. Furthermore, direct molecular interactions have been reported for the pairs CB1R-D2R, A2AR-D2R, and CB1R-A2AR. Here a combination of bimolecular fluorescence complementation and bioluminescence energy transfer techniques was used to identify the occurrence of D2R-CB1R-A2AR hetero-oligomers in living cells.

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