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Title:	Evaluation of logPo/w values of drugs from some molecular structure calculation software
Author:	Pallicer Santana, Juan Manuel; Rosés Pascual, Martí; Ràfols Llach, Clara; Bosch, Elisabeth; Pascual, Rosalía; Port, Ariadna
Other authors:	Universitat de Barcelona
Abstract:	The iridium‐catalyzed asymmetric hydrogenation of several N‐sulfonyl allyl amines is reported. All substrates can be easily obtained by the Ir‐catalyzed isomerization of N‐tosylaziridines reported previously. The commercially available threonine‐derived phosphinite (UbaPHOX) iridium complex has been found to be the best catalyst for this catalytic application, affording β‐methyl amines with good to excellent ee values (up to 94%). The synthetic potential of this novel methodology was demonstrated by the formal synthesis of Lorcaserin and LY‐404187.
Subject(s):	-Lipofília -Química farmacèutica -Lipophilicity -Pharmaceutical chemistry
Rights:	cc-by (c) Pallicer Santana, Juan Manuel et al., 2014 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	IAPC Publishing
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