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dc.contributor | Universitat de Barcelona |
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dc.contributor.author | Duncan, Laramie |
dc.contributor.author | Yilmaz, Zeynep |
dc.contributor.author | Gaspar, Helena |
dc.contributor.author | Walters, Raymond |
dc.contributor.author | Goldstein, Jackie |
dc.contributor.author | Anttila, Verneri |
dc.contributor.author | Bulik-Sullivan, Brendan |
dc.contributor.author | Ripke, Stephan |
dc.contributor.author | Eating Disorders Working Group of the Psychiatric Genomics Consortium |
dc.contributor.author | Thornton, Laura |
dc.contributor.author | Hinney, Anke |
dc.contributor.author | Daly, Mark |
dc.contributor.author | Sullivan, Patrick F. |
dc.contributor.author | Zeggini, Eleftheria |
dc.contributor.author | Breen, Gerome |
dc.contributor.author | Bulik, Cynthia M. |
dc.contributor.author | Fernández Aranda, Fernando |
dc.contributor.author | Rabionet Janssen, Raquel |
dc.date | 2019-09-13T13:34:53Z |
dc.date | 2019-09-13T13:34:53Z |
dc.date | 2017-05-12 |
dc.date | 2019-09-13T13:34:54Z |
dc.identifier.citation | 0002-953X |
dc.identifier.citation | 673624 |
dc.identifier.uri | http://hdl.handle.net/2445/139926 |
dc.description.abstract | Objective: The authors conducted a genome-wide association study of anorexia nervosa and calculated genetic correlations with a series of psychiatric, educational, and metabolic phenotypes. Method: Following uniform quality control and imputation procedures using the 1000 Genomes Project (phase 3) in 12 case-control cohorts comprising 3,495 anorexia nervosa cases and 10,982 controls, the authors performed standard association analysis followed by a meta-analysis across cohorts. Linkage disequilibrium score regression was used to calculate genome-wide common variant heritability (single-nucleotide polymorphism [SNP]-based heritability [h2SNP]), partitioned heritability, and genetic correlations (rg) between anorexia nervosa and 159 other phenotypes. Results: Results were obtained for 10,641,224 SNPs and insertion-deletion variants with minor allele frequencies >1% and imputation quality scores >0.6. The h2SNP of anorexia nervosa was 0.20 (SE=0.02), suggesting that a substantial fraction of the twin-based heritability arises from common genetic variation. The authors identified one genome-wide significant locus on chromosome 12 (rs4622308) in a region harboring a previously reported type 1 diabetes and autoimmune disorder locus. Significant positive genetic correlations were observed between anorexia nervosa and schizophrenia, neuroticism, educational attainment, and high-density lipoprotein cholesterol, and significant negative genetic correlations were observed between anorexia nervosa and body mass index, insulin, glucose, and lipid phenotypes. Conclusions: Anorexia nervosa is a complex heritable phenotype for which this study has uncovered the first genome-wide significant locus. Anorexia nervosa also has large and significant genetic correlations with both psychiatric phenotypes and metabolic traits. The study results encourage a reconceptualization of this frequently lethal disorder as one with both psychiatric and metabolic etiology. |
dc.format | 9 p. |
dc.format | application/pdf |
dc.language.iso | eng |
dc.publisher | American Psychiatric Association |
dc.relation | Versió postprint del document publicat a: https://doi.org/10.1176/appi.ajp.2017.16121402 |
dc.relation | American Journal of Psychiatry, 2017, vol. 174, num. 9, p. 850-858 |
dc.relation | https://doi.org/10.1176/appi.ajp.2017.16121402 |
dc.rights | (c) American Psychiatric Association, 2017 |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Anorèxia nerviosa |
dc.subject | Genètica |
dc.subject | Metabolisme |
dc.subject | Anorexia nervosa |
dc.subject | Genetics |
dc.subject | Metabolism |
dc.title | Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/acceptedVersion |